Review of pharmacotherapeutic targets in Alzheimer's disease and its management using traditional medicinal plants

PN Tripathi, A Lodhi, SN Rai, NK Nandi… - Degenerative …, 2024 - Taylor & Francis
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by
cognitive decline, memory loss, and impaired daily functioning. While there is currently no …

Selenization of small molecule drugs: a new player on the board

C Morán-Serradilla, D Plano, C Sanmartín… - Journal of Medicinal …, 2024 - ACS Publications
There is an urgent need to develop safer and more effective modalities for the treatment of a
wide range of pathologies due to the increasing rates of drug resistance, undesired side …

[HTML][HTML] Mechanistic insights into the potential role of dietary polyphenols and their nanoformulation in the management of Alzheimer's disease

HM Albadrani, P Chauhan, S Ashique, MA Babu… - Biomedicine & …, 2024 - Elsevier
Alzheimer's disease (AD) is a very common neurodegenerative disorder associated with
memory loss and a progressive decline in cognitive activity. The two major …

Cannabidiol-loaded nanocarriers and their therapeutic applications

E Assadpour, A Rezaei, SS Das, BV Krishna Rao… - Pharmaceuticals, 2023 - mdpi.com
Cannabidiol (CBD), one of the most promising constituents isolated from Cannabis sativa,
exhibits diverse pharmacological actions. However, the applications of CBD are restricted …

[HTML][HTML] Photobiomodulation in Alzheimer's disease—A complementary method to state-of-the-art pharmaceutical formulations and nanomedicine?

LM Ailioaie, C Ailioaie, G Litscher - Pharmaceutics, 2023 - mdpi.com
Alzheimer's disease (AD), as a neurodegenerative disorder, usually develops slowly but
gradually worsens. It accounts for approximately 70% of dementia cases worldwide, and is …

Myco-synthesis of silver nanoparticles and their bioactive role against pathogenic microbes

A Abdel-Hadi, D Iqbal, R Alharbi, S Jahan, O Darwish… - Biology, 2023 - mdpi.com
Simple Summary The relatively high prevalence of microbial infections and the rising
resistance to traditional antibiotics are the causes of the need for revolutionary antibiotics …

[HTML][HTML] Three to tango: Inhibitory effect of quercetin and apigenin on acetylcholinesterase, amyloid-β aggregation and acetylcholinesterase-amyloid interaction

I Álvarez-Berbel, A Espargaró, A Viayna, AB Caballero… - Pharmaceutics, 2022 - mdpi.com
One of the pathological hallmarks of Alzheimer's disease (AD) is the formation of amyloid-β
plaques. Since acetylcholinesterase (AChE) promotes the formation of such plaques, the …

Naturally inspired coumarin derivatives in Alzheimer's Disease Drug Discovery: latest advances and current challenges

R Orioli, F Belluti, S Gobbi, A Rampa, A Bisi - Molecules, 2024 - pmc.ncbi.nlm.nih.gov
The main feature of neurodegenerative diseases, including Alzheimer's disease, is the
network of complex and not fully recognized neuronal pathways and targets involved in their …

[HTML][HTML] New advances in the exploration of esterases with PET and fluorescent probes

A Gil-Rivas, B de Pascual-Teresa, I Ortín, A Ramos - Molecules, 2023 - mdpi.com
Esterases are hydrolases that catalyze the hydrolysis of esters into the corresponding acids
and alcohols. The development of fluorescent probes for detecting esterases is of great …

Multitargeted virtual screening and molecular simulation of natural product-like compounds against GSK3β, NMDA-receptor, and BACE-1 for the management of …

D Iqbal, MT Rehman, MF Alajmi, M Alsaweed… - Pharmaceuticals, 2023 - mdpi.com
The complexity of Alzheimer's disease (AD) and several side effects of currently available
medication inclined us to search for a novel natural cure by targeting multiple key regulatory …