Neural algorithms and circuits for motor planning
The brain plans and executes volitional movements. The underlying patterns of neural
population activity have been explored in the context of movements of the eyes, limbs …
population activity have been explored in the context of movements of the eyes, limbs …
Genetically defined neuron types underlying visuomotor transformation in the superior colliculus
The superior colliculus (SC) is a conserved midbrain structure that is important for
transforming visual and other sensory information into motor actions. Decades of …
transforming visual and other sensory information into motor actions. Decades of …
[HTML][HTML] Brain-wide dynamics linking sensation to action during decision-making
Perceptual decisions rely on learned associations between sensory evidence and
appropriate actions, involving the filtering and integration of relevant inputs to prepare and …
appropriate actions, involving the filtering and integration of relevant inputs to prepare and …
Pyramidal cell types drive functionally distinct cortical activity patterns during decision-making
Understanding how cortical circuits generate complex behavior requires investigating the
cell types that comprise them. Functional differences across pyramidal neuron (PyN) types …
cell types that comprise them. Functional differences across pyramidal neuron (PyN) types …
[HTML][HTML] Brain-wide neural activity underlying memory-guided movement
Behavior relies on activity in structured neural circuits that are distributed across the brain,
but most experiments probe neurons in a single area at a time. Using multiple Neuropixels …
but most experiments probe neurons in a single area at a time. Using multiple Neuropixels …
Superior colliculus bidirectionally modulates choice activity in frontal cortex
Action selection occurs through competition between potential choice options. Neural
correlates of choice competition are observed across frontal cortex and downstream …
correlates of choice competition are observed across frontal cortex and downstream …
Functional alterations of the prefrontal circuit underlying cognitive aging in mice
HR Chong, Y Ranjbar-Slamloo, MZH Ho… - Nature …, 2023 - nature.com
Executive function is susceptible to aging. How aging impacts the circuit-level computations
underlying executive function remains unclear. Using calcium imaging and optogenetic …
underlying executive function remains unclear. Using calcium imaging and optogenetic …
[HTML][HTML] Dynamic ensemble balance in direct-and indirect-pathway striatal projection neurons underlying decision-related action selection
The posterior dorsal striatum (pDS) plays an essential role in sensory-guided decision-
making. However, it remains unclear how the antagonizing direct-and indirect-pathway …
making. However, it remains unclear how the antagonizing direct-and indirect-pathway …
Sensory coding and the causal impact of mouse cortex in a visual decision
Correlates of sensory stimuli and motor actions are found in multiple cortical areas, but such
correlates do not indicate whether these areas are causally relevant to task performance …
correlates do not indicate whether these areas are causally relevant to task performance …
Functional organisation of the mouse superior colliculus
The superior colliculus (SC) is a highly conserved area of the mammalian midbrain that is
widely implicated in the organisation and control of behaviour. SC receives input from a …
widely implicated in the organisation and control of behaviour. SC receives input from a …