Neural algorithms and circuits for motor planning

HK Inagaki, S Chen, K Daie… - Annual review of …, 2022 - annualreviews.org
The brain plans and executes volitional movements. The underlying patterns of neural
population activity have been explored in the context of movements of the eyes, limbs …

Genetically defined neuron types underlying visuomotor transformation in the superior colliculus

J Cang, C Chen, C Li, Y Liu - Nature Reviews Neuroscience, 2024 - nature.com
The superior colliculus (SC) is a conserved midbrain structure that is important for
transforming visual and other sensory information into motor actions. Decades of …

[HTML][HTML] Brain-wide dynamics linking sensation to action during decision-making

A Khilkevich, M Lohse, R Low, I Orsolic, T Bozic… - Nature, 2024 - nature.com
Perceptual decisions rely on learned associations between sensory evidence and
appropriate actions, involving the filtering and integration of relevant inputs to prepare and …

Pyramidal cell types drive functionally distinct cortical activity patterns during decision-making

S Musall, XR Sun, H Mohan, X An, S Gluf, SJ Li… - Nature …, 2023 - nature.com
Understanding how cortical circuits generate complex behavior requires investigating the
cell types that comprise them. Functional differences across pyramidal neuron (PyN) types …

[HTML][HTML] Brain-wide neural activity underlying memory-guided movement

S Chen, Y Liu, ZA Wang, J Colonell, LD Liu, H Hou… - Cell, 2024 - cell.com
Behavior relies on activity in structured neural circuits that are distributed across the brain,
but most experiments probe neurons in a single area at a time. Using multiple Neuropixels …

Superior colliculus bidirectionally modulates choice activity in frontal cortex

A Thomas, W Yang, C Wang, SL Tipparaju… - Nature …, 2023 - nature.com
Action selection occurs through competition between potential choice options. Neural
correlates of choice competition are observed across frontal cortex and downstream …

Functional alterations of the prefrontal circuit underlying cognitive aging in mice

HR Chong, Y Ranjbar-Slamloo, MZH Ho… - Nature …, 2023 - nature.com
Executive function is susceptible to aging. How aging impacts the circuit-level computations
underlying executive function remains unclear. Using calcium imaging and optogenetic …

[HTML][HTML] Dynamic ensemble balance in direct-and indirect-pathway striatal projection neurons underlying decision-related action selection

S Tang, L Cui, J Pan, N Xu - Cell Reports, 2024 - cell.com
The posterior dorsal striatum (pDS) plays an essential role in sensory-guided decision-
making. However, it remains unclear how the antagonizing direct-and indirect-pathway …

Sensory coding and the causal impact of mouse cortex in a visual decision

P Zatka-Haas, NA Steinmetz, M Carandini, KD Harris - Elife, 2021 - elifesciences.org
Correlates of sensory stimuli and motor actions are found in multiple cortical areas, but such
correlates do not indicate whether these areas are causally relevant to task performance …

Functional organisation of the mouse superior colliculus

T Wheatcroft, AB Saleem, SG Solomon - Frontiers in neural circuits, 2022 - frontiersin.org
The superior colliculus (SC) is a highly conserved area of the mammalian midbrain that is
widely implicated in the organisation and control of behaviour. SC receives input from a …