Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide, and fatty acid
metabolism has been well studied. Short-chain fatty acids (SCFAs) have been less …

Abstract Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme involved in the
detoxification of alcohol-derived acetaldehyde and endogenous aldehydes. The inactivating …

Fibrinogen conversion into insoluble fibrin and the formation of a stable clot is the final step
of the coagulation cascade. Fibrin clot porosity and its susceptibility to plasmin-mediated …

Introduction Chronic low-grade inflammation is an important aspect of morbidity and
mortality in older adults. The level of circulating pro-inflammatory cytokines (interleukin (IL) …

The CCL2-CCR2 axis is one of the major chemokine signaling pathways that has received
special attention because of its function in the development and progression of …

Aging is characterized by progressive functional deterioration with increased risk of
mortality. It is a complex biological process driven by a multitude of intertwined mechanisms …

The design of human model systems is highly relevant to unveil the underlying mechanisms
of aging and to provide insights on potential interventions to extend human health and life …

Obesity epidemic reached the dimensions of a real global health crisis with more than one
billion people worldwide living with obesity. Multiple obesity-related mechanisms cause …

Background This study sought to elucidate the associations of cardiometabolic index (CMI),
as a metabolism-related index, with all-cause and cardiovascular mortality among the older …

Atherosclerotic cardiovascular disease (CVD) remains the leading cause of mortality
worldwide. While conventional risk factors have been studied and managed, CVD continues …