Colorectal cancer (CRC) is highly heterogeneous at the genetic and molecular level, which
has major repercussions on the efficacy of immunotherapy. A small subset of CRCs exhibit …

Systemic inflammation is a marker of poor prognosis preoperatively present in around 20%-
40% of colorectal cancer patients. The hallmarks of systemic inflammation include an …

The characterization of the microenvironment of human tumors led to the description of
tertiary lymphoid structures (TLS) characterized by mature dendritic cells in a T‐cell zone …

Tertiary lymphoid structures (TLS) are ectopic lymphoid formations found in inflamed,
infected, or tumoral tissues. They exhibit all the characteristics of structures in the lymph …

Tertiary lymphoid structures (TLS) are ectopic lymphoid aggregates that reflect lymphoid
neogenesis occurring in tissues at sites of inflammation. They are detected in tumors where …

The immune system plays a crucial role in cancer development either by fostering tumor
growth or destroying tumor cells, which has open new avenues for cancer immunotherapy. It …

Limited representation of intratumoral immune cells is a major barrier to tumor control.
However, simply enhancing immune responses in tumor-draining lymph nodes or through …

Background: While clinical outcomes from colorectal cancer (CRC) are influenced by stage
at diagnosis and treatment, mounting evidence suggests that an enhanced lymphocytic …

The outcome of tumors results from genetic and epigenetic modifications of the transformed
cells and also from the interactions of the malignant cells with their tumor microenvironment …

Colorectal cancer (CRC) is one of the most common cancer worldwide, with a growing
impact on public health and clinical management. Immunotherapy has shown promise in the …