Targeting angiogenesis in oncology, ophthalmology and beyond
Angiogenesis is an essential process in normal development and in adult physiology, but
can be disrupted in numerous diseases. The concept of targeting angiogenesis for treating …
can be disrupted in numerous diseases. The concept of targeting angiogenesis for treating …
Digital technology, tele-medicine and artificial intelligence in ophthalmology: A global perspective
The simultaneous maturation of multiple digital and telecommunications technologies in
2020 has created an unprecedented opportunity for ophthalmology to adapt to new models …
2020 has created an unprecedented opportunity for ophthalmology to adapt to new models …
Scarless wound healing programmed by core-shell microneedles
Effective reprogramming of chronic wound healing remains challenging due to the limited
drug delivery efficacy hindered by physiological barriers, as well as the inappropriate dosing …
drug delivery efficacy hindered by physiological barriers, as well as the inappropriate dosing …
[HTML][HTML] C5 inhibitor avacincaptad pegol for geographic atrophy due to age-related macular degeneration: a randomized pivotal phase 2/3 trial
GJ Jaffe, K Westby, KG Csaky, J Monés, JA Pearlman… - Ophthalmology, 2021 - Elsevier
Purpose The complement pathway may play a key role in the pathogenesis of age-related
macular degeneration (AMD). The safety and efficacy of avacincaptad pegol (Zimura …
macular degeneration (AMD). The safety and efficacy of avacincaptad pegol (Zimura …
Age-related macular degeneration
Age-related macular degeneration is a leading cause of visual impairment and severe vision
loss. Clinically, it is classified as early-stage (medium-sized drusen and retinal pigmentary …
loss. Clinically, it is classified as early-stage (medium-sized drusen and retinal pigmentary …
[HTML][HTML] Age-related macular degeneration: Epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy
Y Deng, L Qiao, M Du, C Qu, L Wan, J Li, L Huang - Genes & diseases, 2022 - Elsevier
Age-related macular degeneration (AMD) is a complex eye disorder and is the leading
cause of incurable blindness worldwide in the elderly. Clinically, AMD initially affects the …
cause of incurable blindness worldwide in the elderly. Clinically, AMD initially affects the …
Incomplete response to Anti-VEGF therapy in neovascular AMD: Exploring disease mechanisms and therapeutic opportunities
PS Mettu, MJ Allingham, SW Cousins - Progress in retinal and eye …, 2021 - Elsevier
Intravitreal anti-vascular endothelial growth factor (VEGF) drugs have revolutionized the
treatment of neovascular age-related macular degeneration (NVAMD). However, many …
treatment of neovascular age-related macular degeneration (NVAMD). However, many …
Next generation antibody drugs: pursuit of the'high-hanging fruit'
PJ Carter, GA Lazar - Nature Reviews Drug Discovery, 2018 - nature.com
Antibodies are the most rapidly growing drug class and have a major impact on human
health, particularly in oncology, autoimmunity and chronic inflammatory diseases. Many of …
health, particularly in oncology, autoimmunity and chronic inflammatory diseases. Many of …
Aptamers as targeted therapeutics: current potential and challenges
Nucleic acid aptamers, often termed'chemical antibodies', are functionally comparable to
traditional antibodies, but offer several advantages, including their relatively small physical …
traditional antibodies, but offer several advantages, including their relatively small physical …
Molecular mechanism of VEGF and its role in pathological angiogenesis
Over the last seven decades, a significant scientific contribution took place in the delineation
of the implications of vascular endothelial‐derived growth factor (VEGF) in the processes of …
of the implications of vascular endothelial‐derived growth factor (VEGF) in the processes of …