Targeting angiogenesis in oncology, ophthalmology and beyond

Y Cao, R Langer, N Ferrara - Nature Reviews Drug Discovery, 2023 - nature.com
Angiogenesis is an essential process in normal development and in adult physiology, but
can be disrupted in numerous diseases. The concept of targeting angiogenesis for treating …

Digital technology, tele-medicine and artificial intelligence in ophthalmology: A global perspective

JPO Li, H Liu, DSJ Ting, S Jeon, RVP Chan… - Progress in retinal and …, 2021 - Elsevier
The simultaneous maturation of multiple digital and telecommunications technologies in
2020 has created an unprecedented opportunity for ophthalmology to adapt to new models …

Scarless wound healing programmed by core-shell microneedles

Y Zhang, S Wang, Y Yang, S Zhao, J You… - Nature …, 2023 - nature.com
Effective reprogramming of chronic wound healing remains challenging due to the limited
drug delivery efficacy hindered by physiological barriers, as well as the inappropriate dosing …

[HTML][HTML] C5 inhibitor avacincaptad pegol for geographic atrophy due to age-related macular degeneration: a randomized pivotal phase 2/3 trial

GJ Jaffe, K Westby, KG Csaky, J Monés, JA Pearlman… - Ophthalmology, 2021 - Elsevier
Purpose The complement pathway may play a key role in the pathogenesis of age-related
macular degeneration (AMD). The safety and efficacy of avacincaptad pegol (Zimura …

Age-related macular degeneration

P Mitchell, G Liew, B Gopinath, TY Wong - The Lancet, 2018 - thelancet.com
Age-related macular degeneration is a leading cause of visual impairment and severe vision
loss. Clinically, it is classified as early-stage (medium-sized drusen and retinal pigmentary …

[HTML][HTML] Age-related macular degeneration: Epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy

Y Deng, L Qiao, M Du, C Qu, L Wan, J Li, L Huang - Genes & diseases, 2022 - Elsevier
Age-related macular degeneration (AMD) is a complex eye disorder and is the leading
cause of incurable blindness worldwide in the elderly. Clinically, AMD initially affects the …

Incomplete response to Anti-VEGF therapy in neovascular AMD: Exploring disease mechanisms and therapeutic opportunities

PS Mettu, MJ Allingham, SW Cousins - Progress in retinal and eye …, 2021 - Elsevier
Intravitreal anti-vascular endothelial growth factor (VEGF) drugs have revolutionized the
treatment of neovascular age-related macular degeneration (NVAMD). However, many …

Next generation antibody drugs: pursuit of the'high-hanging fruit'

PJ Carter, GA Lazar - Nature Reviews Drug Discovery, 2018 - nature.com
Antibodies are the most rapidly growing drug class and have a major impact on human
health, particularly in oncology, autoimmunity and chronic inflammatory diseases. Many of …

Aptamers as targeted therapeutics: current potential and challenges

J Zhou, J Rossi - Nature reviews Drug discovery, 2017 - nature.com
Nucleic acid aptamers, often termed'chemical antibodies', are functionally comparable to
traditional antibodies, but offer several advantages, including their relatively small physical …

Molecular mechanism of VEGF and its role in pathological angiogenesis

A Ahmad, MI Nawaz - Journal of Cellular Biochemistry, 2022 - Wiley Online Library
Over the last seven decades, a significant scientific contribution took place in the delineation
of the implications of vascular endothelial‐derived growth factor (VEGF) in the processes of …