Advances in metabolic engineering of Corynebacterium glutamicum to produce high-value active ingredients for food, feed, human health, and well-being

S Wolf, J Becker, Y Tsuge, H Kawaguchi… - Essays in …, 2021‏ - portlandpress.com
The soil microbe Corynebacterium glutamicum is a leading workhorse in industrial
biotechnology and has become famous for its power to synthetise amino acids and a range …

Plant phenolics as functional food ingredients

C Santos-Buelga, AM González-Paramás… - Advances in food and …, 2019‏ - Elsevier
Phenolic compounds have attracted much attention in recent times as their dietary intake
has been associated with the prevention of some chronic and degenerative diseases that …

The antidiabetic mechanisms of polyphenols related to increased glucagon-like peptide-1 (GLP1) and insulin signaling

JA Dominguez Avila, J Rodrigo Garcia… - Molecules, 2017‏ - mdpi.com
Type-2 diabetes mellitus (T2DM) is an endocrine disease related to impaired/absent insulin
signaling. Dietary habits can either promote or mitigate the onset and severity of T2DM …

New insights on the use of polyphenols as natural preservatives and their emerging safety concerns

FK Ofosu, EBM Daliri, F Elahi, R Chelliah… - … in Sustainable Food …, 2020‏ - frontiersin.org
Polyphenols are natural high-valued secondary metabolites of plant that demonstrate strong
antimicrobial potential as natural preservatives besides their well-established health …

[HTML][HTML] From fighting critters to saving lives: polyphenols in plant defense and human health

A Stiller, K Garrison, K Gurdyumov, J Kenner… - International journal of …, 2021‏ - mdpi.com
Polyphenols, such as flavonoids and phenolic acids, are a group of specialized metabolites
in plants that largely aid in plant defense by deterring biotic stressors and alleviating abiotic …

Biosynthesis, Chemistry, and Pharmacology of Polyphenols from Chinese Salvia Species: A Review

J Wang, J Xu, X Gong, M Yang, C Zhang, M Li - Molecules, 2019‏ - mdpi.com
Salvia species find widespread application in food and pharmaceutical products owing to
their large polyphenol content. The main polyphenols in Chinese Salvia species are …

Production of plant-derived polyphenols in microorganisms: current state and perspectives

L Milke, J Aschenbrenner, J Marienhagen… - Applied Microbiology …, 2018‏ - Springer
Plants synthesize several thousand different polyphenols of which many have the potential
to aid in preventing or treating cancer, cardiovascular, and neurodegenerative diseases …

Membrane manipulation by free fatty acids improves microbial plant polyphenol synthesis

A Tharmasothirajan, J Melcr, J Linney… - Nature …, 2023‏ - nature.com
Microbial synthesis of nutraceutically and pharmaceutically interesting plant polyphenols
represents a more environmentally friendly alternative to chemical synthesis or plant …

Recent advances in metabolic engineering of Corynebacterium glutamicum for bioproduction of value-added aromatic chemicals and natural products

T Kogure, M Inui - Applied microbiology and biotechnology, 2018‏ - Springer
Recent progress in synthetic and systems metabolic engineering technologies has explored
the potential of microbial cell factories for the production of industrially relevant bulk and fine …

Corynebacterium glutamicum as platform for the production of hydroxybenzoic acids

N Kallscheuer, J Marienhagen - Microbial cell factories, 2018‏ - Springer
Background Hydroxybenzoic acids are industrially relevant aromatic compounds, which also
play key roles in the microbial carbon metabolism, eg, as precursors for the synthesis of …