Much has been learned since the early 1960s about histone post-translational modifications
(PTMs) and how they affect DNA-templated processes at the molecular level. This …

Chromatin organization plays a critical role in cellular function by regulating access to
genetic information. However, understanding chromatin folding is challenging due to its …

Nucleosomes, the basic structural units of chromatin, hinder recruitment and activity of
various DNA repair proteins, necessitating modifications that enhance DNA accessibility …

Epigenetic modifications of chromatin play a critical role in regulating the fidelity of the
genetic code and in controlling the translation of genetic information into the protein …

The epigenome—the chemical modifications and chromatin-related packaging of the
genome—enables the same genetic template to be activated or repressed in different …

Nucleosomes containing the histone variant H2A. Z are important for gene transcription
initiation and termination, chromosome segregation and DNA double-strand break repair …

Nucleosome DNA unwrap** and its disassembly into hexasomes and tetrasomes is
necessary for genomic access and plays an important role in transcription regulation …

The intricacies of the 3D hierarchical organization of the genome have been approached by
many creative modeling studies. The specific model/simulation technique combination …

The histone H2A variant H2A. W occupies transposons and thus prevents access to them in
Arabidopsis thaliana. H2A. W is deposited by the chromatin remodeler DDM1, which also …

Each nucleosome contains four types of histone proteins, each with a histone tail. These
tails are essential for the epigenetic regulation of gene expression through post-translational …