Recent years have seen much excitement over the possibility that adult mammalian stem
cells may be capable of differentiating across tissue lineage boundaries, and as such may …

The monolayer of endothelial cells lining the vessel wall forms a semipermeable barrier (in
all tissue except the relatively impermeable blood–brain and inner retinal barriers) that …

Tissue injury evokes highly conserved, tightly regulated inflammatory responses and less
well-understood host repair responses. Both inflammation and repair involve the …

Bone marrow (BM) contains hematopoietic stem cells (HSCs), which differentiate into every
type of mature blood cell; endothelial cell progenitors; and marrow stromal cells, also called …

Background The acute respiratory distress syndrome (ARDS), a clinical complication of
severe acute lung injury (ALI) in humans, is a leading cause of morbidity and mortality in …

The origin of fibroblasts in pulmonary fibrosis is assumed to be intrapulmonary, but their
extrapulmonary origin and especially derivation from bone marrow (BM) progenitor cells has …

Rationale: Bronchopulmonary dysplasia (BPD) and emphysema are characterized by
arrested alveolar development or loss of alveoli; both are significant global health problems …

Stem cell plasticity refers to the ability of adult stem cells to acquire mature phenotypes that
are different from their tissue of origin. Adult bone marrow cells (BMCs) include two …

EXECUTIVE SUMMARY The University of Vermont College of Medicine and the Vermont
Lung Center, with support of the National Heart, Lung, and Blood Institute (NHLBI), the …

Most reviews of adult stem cells focus on the relatively undifferentiated cells dedicated to the
renewal of rapidly proliferating tissues, such as the skin, gut and blood. By contrast, there is …