In vivo two-photon calcium imaging (2PCI) is a technique used for recording neuronal
activity in the intact brain. It is based on the principle that, when neurons fire action …

Multiphoton fluorescence microscopy (MPFM) has been a game-changer for optical
imaging, particularly for studying biological tissues deep within living organisms. MPFM …

Calcium imaging with protein-based indicators, is widely used to follow neural activity in
intact nervous systems, but current protein sensors report neural activity at timescales much …

Biological computing (or biocomputing) offers potential advantages over silicon-based
computing in terms of faster decision-making, continuous learning during tasks, and greater …

The most successful obesity therapeutics, glucagon-like peptide-1 receptor (GLP1R)
agonists, cause aversive responses such as nausea and vomiting,, effects that may …

Early-life inflammation increases the risk for depression in later life. Here, we demonstrate
how early-life inflammation causes adolescent depressive-like symptoms: by altering the …

How the brain stores a sequence in memory remains largely unknown. We investigated the
neural code underlying sequence working memory using two-photon calcium imaging to …

Human organoids recapitulating the cell-type diversity and function of their target organ are
valuable for basic and translational research. We developed light-sensitive human retinal …

Fiber photometry enables recording of population neuronal calcium dynamics in awake
mice. While the popularity of fiber photometry has grown in recent years, it remains unclear …

Two-photon microscopy has enabled high-resolution imaging of neuroactivity at depth within
scattering brain tissue. However, its various realizations have not overcome the tradeoffs …