Therapeutic potential of natural compounds in Subarachnoid Haemorrhage

J Tan, H Zhu, Y Zeng, J Li, Y Zhao, M Li - Neuroscience, 2024 - Elsevier
Subarachnoid hemorrhage (SAH) is a common and fatal cerebrovascular disease with high
morbidity, mortality and very poor prognosis worldwide. SAH can induce a complex series of …

Sirtuins as potential targets for neuroprotection: mechanisms of early brain injury induced by subarachnoid hemorrhage

K Lei, R Wu, J Wang, X Lei, E Zhou, R Fan… - Translational Stroke …, 2024 - Springer
Subarachnoid hemorrhage (SAH) is a prevalent cerebrovascular disease with significant
global mortality and morbidity rates. Despite advancements in pharmacological and surgical …

Salvianolic acid B ameliorates neuroinflammation and neuronal injury via blocking NLRP3 inflammasome and promoting SIRT1 in experimental subarachnoid …

D **a, J Yuan, D Wu, H Dai, Z Zhuang - Frontiers in Immunology, 2023 - frontiersin.org
The nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain
containing 3 (NLRP3) inflammasome-mediated immuno-inflammatory response plays a …

Semaglutide alleviates early brain injury following subarachnoid hemorrhage by suppressing ferroptosis and neuroinflammation via SIRT1 pathway

L Chen, H Xu, C Zhang, J He… - American Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Objectives: Subarachnoid hemorrhage (SAH) is a major cause of incapacity and death,
imposing a significant economic burden globally. Additionally, SAH is the third most …

New insights into the relationship of mitochondrial metabolism and atherosclerosis

Z Wang, W Sun, K Zhang, X Ke, Z Wang - Cellular Signalling, 2024 - Elsevier
Atherosclerotic cardiovascular and cerebrovascular diseases are the number one killer of
human health. In view of the important role of mitochondria in the formation and evolution of …

Development and Validation of a Prechiasmatic Mouse Model of Subarachnoid Hemorrhage to Measure Long‐Term Cognitive Deficits

D Diwan, J Mehla, JW Nelson, JD Quirk… - Advanced …, 2024 - Wiley Online Library
Controllable and reproducible animal models of aneurysmal subarachnoid hemorrhage
(SAH) are crucial for the systematic study of the pathophysiology and treatment of this …

Controlling the familywise error rate in widefield optical neuroimaging of functional connectivity in mice

BR White, C Chan, T Adepoju, RT Shinohara… - …, 2023 - spiedigitallibrary.org
Significance Statistical inference in functional neuroimaging is complicated by the multiple
testing problem and spatial autocorrelation. Common methods in functional magnetic …

Pterostilbene Attenuates Subarachnoid Hemorrhage‐Induced Brain Injury through the SIRT1‐Dependent Nrf2 Signaling Pathway

Z Zhang, J Fang, J Zhou, F Ding, G Zhou… - Oxidative medicine …, 2022 - Wiley Online Library
Neuroinflammatory injury, oxidative insults, and neuronal apoptosis are major causes of
poor outcomes after subarachnoid hemorrhage (SAH). Pterostilbene (PTE), an analog of …

Sirt1 activation promotes long-term functional recovery after subarachnoid hemorrhage in rats

D Chu, X Li, X Qu, D Diwan, DS Warner, GJ Zipfel… - Neurocritical care, 2023 - Springer
Background An increase in sirtuin 1 (SIRT1) reportedly attenuates early brain injury, delayed
cerebral ischemia, and short-term neurologic deficits in rodent models of subarachnoid …

Conditioning-based therapeutics for aneurysmal subarachnoid hemorrhage–A critical review

S Pugazenthi, AJ Norris, DC Lauzier… - Journal of Cerebral …, 2024 - journals.sagepub.com
Aneurysmal subarachnoid hemorrhage (SAH) carries significant mortality and morbidity,
with nearly half of SAH survivors having major cognitive dysfunction that impairs their …