Ovarian cancer varies widely in frequency among different geographic regions and ethnic
groups, with a high incidence in Northern Europe and the United States, and a low …

Hereditary breast and ovarian cancer due to mutations in the BRCA1 and BRCA2 genes is
the most common cause of hereditary forms of both breast and ovarian cancer. The overall …

Background: BRCA1 and BRCA2 mutations in general populations and in various types of
cancers have not been well characterized. We investigated the presence of these mutations …

Context Attempts to determine the clinical significance of BRCA1/2 mutations in ovarian
cancer have produced conflicting results. Objective To determine the relationships between …

Purpose Mutations in the BRCA1 and BRCA2 genes confer greater risk of develo** breast
cancer. We determined whether tumor pathologic features and clinical features differ in …

Purpose We evaluated the clinical impact of germ-line BRCA1/2 mutations in patients with
epithelial ovarian cancer (EOC) on responses to first and subsequent lines of chemotherapy …

PURPOSE: To compare magnetic resonance (MR) imaging with conventional imaging in
screening high-risk women. MATERIALS AND METHODS: This prospective trial included …

ContextMost hereditary ovarian cancers are associated with germline mutations in BRCA1
or BRCA2. Attempts to define the clinical significance of BRCA mutation status in ovarian …

BACKGROUND The objective of this study was to determine the clinical characteristics,
treatment response, and frequency of p53 overexpression in Ashkenazi Jewish women with …

BRCA1, a multi-domain protein, is mutated in a large percentage of hereditary breast and
ovarian cancers. BRCA1 is most often mutated in three domains or regions: the N-terminal …