The microenvironment within a solid tumor is heterogeneous with regions being both acidic
and hypoxic. As a result of this, cancer cells upregulate genes that allow survival in such …

Technetium radionuclide (99mTc) has excellent extent of disintegration properties and
occupies a special place in the field of nuclear medicinal chemistry and other health …

Three discrete carbohydrate-appended 2, 2 '-dipicolylamine ligands were complexed to the
{M (CO) 3}+(M= 99mTc/Re) core: 2-(bis (2-pyridinylmethyl) amino) ethyl-β-d …

By analogy to the recently described single amino acid chelate (SAAC) technology for
complexation of the {M (CO) 3}+ core (M= Tc, Re), a series of tridentate ligands containing …

The copper (I)-catalyzed azide–alkyne cycloaddition (CuAAC) click reaction was used to
incorporate alkyne-functionalized dipicolylamine (DPA) ligands (1 and 3) for fac-[MI (CO) …

With the long-term goal of develo** theranostic agents for applications in nuclear
medicine, in this work we evaluated the well-known NOTA and NODAGA chelators as …

For radiotherapy, biomolecules such as intact antibodies, antibody fragments, peptides,
DNAs and other oligomers have all been labeled with radiorhenium (186Re and 188Re) …

Two novel bifunctional chelating agents, which are bistriazole-based polyaminocarboxylic
acids, have been designed and synthesised in high yields. An elegant synthetic approach …

The syntheses of the 4-n-propyl and 4-phenyl substituted fac-Re (CO) 3 complexes of the
tridentate “click” ligand (2, 6-bis (4-substituted-1, 2, 3-triazol-1-ylmethyl) pyridine) are …

Technetium tricarbonyl chemistry has been a subject of interest in radiopharmaceutical
development over the past decade. Despite the extensive work done on develo** …