Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

Primordial germ cells (PGCs), the precursors of sperm and eggs, are established in
perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a …

Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is widely used to map
histone marks and transcription factor binding throughout the genome. Here we present …

Chromatin accessibility, or the physical access to chromatinized DNA, is a widely studied
characteristic of the eukaryotic genome. As active regulatory DNA elements are generally …

As the second dimension to the genome, the epigenome contains key information specific to
every type of cells. Thousands of human epigenome maps have been produced in recent …

Drastic epigenetic reprogramming takes place during preimplantation development, leading
to the conversion of terminally differentiated gametes to a totipotent embryo. Deficiencies in …

Adult germline stem cells (AGSCs) self-renew (Thy1+ enriched) or commit to gametogenesis
(Kit+ enriched). To better understand how chromatin regulates AGSC biology and …