Abstract The glucagon-like peptide-1 (GLP-1) receptor, known as GLP-1R, is a vital
component of the G protein-coupled receptor (GPCR) family and is found primarily on the …

Immune tolerance deletes or suppresses autoreactive lymphocytes and is established at
multiple levels during the development, activation and effector phases of T and B cells …

Inflammation contributes to many chronic conditions. It is often associated with circulating
pro-inflammatory cytokines and immune cells. GLP-1 levels correlate with disease severity …

Methods| We used the TriNetX platform to access deidentified electronic health records of
101.2 million patients, including 7.4 million with T2D from 59 health care organizations …

Summary Glucagon-like peptide-1 receptor (GLP-1R) is a key regulator of glucose
metabolism known to be expressed by pancreatic β cells. We herein investigated the role of …

Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have emerged as promising
therapeutic agents with potent anti-inflammatory properties and diverse clinical implications …

Macrophages play diverse roles in development, homeostasis, and immunity. Accordingly,
the dysfunction of macrophages is involved in the occurrence and progression of various …

It is well established that decreases in plasma leptin levels, as with fasting, signal starvation
and elicit appropriate physiological responses, such as increasing the drive to eat and …

Recent clinical trials in people with type 2 diabetes have demonstrated beneficial actions on
heart and kidney outcomes following treatment with GLP-1RAs. In part, these actions are …

Obesity and chronic low-grade inflammation, often occurring together, significantly
contribute to severe metabolic and inflammatory conditions like type 2 diabetes (T2D) …