Cardiac function is determined by the dynamic equilibrium of various cell types and the
extracellular matrix that composes the heart. Cardiovascular diseases (CVDs), especially …

Pyroptosis is a pro-inflammatory type of regulated cell death (RCD) characterized by
gasdermin D (GSDMD)-mediated membrane pore formation, cell swelling and rapid lysis …

Pyroptosis is a kind of pro-inflammatory cell death. Compared with autophagy and
apoptosis, pyroptosis has unique characteristics in morphology and mechanism …

Astragalus membranaceus is a traditional Chinese medicine and has been widely used in
treating cardiovascular diseases (CVDs), such as asthma, edema, and chest tightness …

Heart failure (HF) is a complex clinical syndrome caused by various cardiovascular
diseases. Its main pathogenesis includes cardiomyocyte loss, myocardial energy …

Apigenin is considered the most-known natural flavonoid and is abundant in a wide variety
of fruits and vegetables. A high fat diet (HFD) can induce liver injury and hepatocyte death in …

Pyroptosis is a kind of programmed cell death closely related to inflammation. The pathways
that mediate pyroptosis can be divided into the Caspase-1-dependent canonical pathway …

Cell death occurs in various tissues and organs in the body. It is a physiological or
pathological process that has different effects. It is of great significance in maintaining the …

PANoptosis, a complex form of proinflammatory programmed cell death, including
apoptosis, pyroptosis and necroptosis, has been an emerging concept in recent years that …

Toll-like receptor 4 (TLR4), a key pattern recognition receptor, initiates the innate immune
response and leads to chronic and acute inflammation. In the past decades, accumulating …