The power and the promise of DNA methylation markers
PW Laird - Nature Reviews Cancer, 2003 - nature.com
The past few years have seen an explosion of interest in the epigenetics of cancer. This has
been a consequence of both the exciting coalescence of the chromatin and DNA …
been a consequence of both the exciting coalescence of the chromatin and DNA …
CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future
M Esteller - Oncogene, 2002 - nature.com
We have come a long way since the first reports of the existence of aberrant DNA
methylation in human cancer. Hypermethylation of CpG islands located in the promoter …
methylation in human cancer. Hypermethylation of CpG islands located in the promoter …
Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling
Background In recent years the Illumina HumanMethylation450 (HM450) BeadChip has
provided a user-friendly platform to profile DNA methylation in human samples. However …
provided a user-friendly platform to profile DNA methylation in human samples. However …
CpG island methylator phenotype in cancer
JP Issa - Nature Reviews Cancer, 2004 - nature.com
DNA hypermethylation in CpG-rich promoters is now recognized as a common feature of
human neoplasia. However, the pathophysiology of hyper-methylation (why, when, where) …
human neoplasia. However, the pathophysiology of hyper-methylation (why, when, where) …
Methyl-CpG-binding domain proteins: readers of the epigenome
How DNA methylation is interpreted and influences genome regulation remains largely
unknown. Proteins of the methyl-CpG-binding domain (MBD) family are primary candidates …
unknown. Proteins of the methyl-CpG-binding domain (MBD) family are primary candidates …
High Levels of Aberrant DNA Methylation in Helicobacter pylori–Infected Gastric Mucosae and its Possible Association with Gastric Cancer Risk
T Maekita, K Nakazawa, M Mihara, T Nakajima… - Clinical Cancer …, 2006 - AACR
Introduction: Risk prediction of gastric cancers is important to implement appropriate
screening procedures. Although aberrant DNA methylation is deeply involved in gastric …
screening procedures. Although aberrant DNA methylation is deeply involved in gastric …
Cancer epigenetics
PW Laird - Human molecular genetics, 2005 - academic.oup.com
The field of cancer epigenetics is evolving rapidly on several fronts. Advances in our
understanding of chromatin structure, histone modification, transcriptional activity and DNA …
understanding of chromatin structure, histone modification, transcriptional activity and DNA …
Senescent cells harbour features of the cancer epigenome
HA Cruickshanks, T McBryan, DM Nelson… - Nature cell …, 2013 - nature.com
Altered DNA methylation and associated destabilization of genome integrity and function is
a hallmark of cancer. Replicative senescence is a tumour suppressor process that imposes …
a hallmark of cancer. Replicative senescence is a tumour suppressor process that imposes …
DNA methylation pattern changes upon long‐term culture and aging of human mesenchymal stromal cells
Within 2–3 months of in vitro culture‐expansion, mesenchymal stromal cells (MSC) undergo
replicative senescence characterized by cell enlargement, loss of differentiation potential …
replicative senescence characterized by cell enlargement, loss of differentiation potential …
Inflammatory Processes Triggered by Helicobacter pylori Infection Cause Aberrant DNA Methylation in Gastric Epithelial Cells
T Niwa, T Tsukamoto, T Toyoda, A Mori, H Tanaka… - Cancer research, 2010 - AACR
Altered patterns of DNA methylation associated with Helicobacter pylori (HP) infection of
gastric epithelial cells are thought to contribute to gastric cancer risk. However, it is unclear …
gastric epithelial cells are thought to contribute to gastric cancer risk. However, it is unclear …