The molecular mechanisms of cellular insulin action have been the focus of much
investigation since the discovery of the hormone 100 years ago. Insulin action is impaired in …

The 14-3-3 proteins are a family of conserved regulatory molecules expressed in all
eukaryotic cells. A striking feature of the 14-3-3 proteins is their ability to bind a multitude of …

Recent studies using magnetic resonance spectroscopy have shown that decreased insulin-
stimulated muscle glycogen synthesis due to a defect in insulin-stimulated glucose transport …

Insulin resistance contributes importantly to the pathophysiology of type 2 diabetes mellitus.
One mechanism mediating insulin resistance may involve the phosphorylation of serine …

Schematic illustration of major signaling pathways of insulin action. The phosphorylated
insulin receptor binds and phosphorylates IRS proteins and Shc, which bind differentially to …

Abstract The 14‐3‐3 proteins constitute a family of conserved proteins present in all
eukaryotic organisms so far investigated. These proteins have attracted interest because …

We have solved the high-resolution X-ray structure of 14-3-3 bound to two different
phosphoserine peptides, representing alternative substrate-binding motifs. These structures …

The 14-3-3 proteins are a family of abundant, widely expressed 28–33-kDa acidic
polypeptides that spontaneously self-assemble as dimers. The 14-3-3 proteins were first …

This meta-proteomics review focused on proteins identified as candidate biomarkers of beef
tenderness by comparing extreme groups of tenderness using two-dimensional …

Comprehensive characterization of the post-mortem muscle proteome defines a
fundamental goal in meat proteomics. During the last decade, proteomics tools have been …