The use of animal models in diabetes research
AJF King - British journal of pharmacology, 2012 - Wiley Online Library
Diabetes is a disease characterized by a relative or absolute lack of insulin, leading to
hyperglycaemia. There are two main types of diabetes: type 1 diabetes and type 2 diabetes …
hyperglycaemia. There are two main types of diabetes: type 1 diabetes and type 2 diabetes …
Advances in the cellular immunological pathogenesis of type 1 diabetes
M Li, LJ Song, XY Qin - Journal of cellular and molecular …, 2014 - Wiley Online Library
Type 1 diabetes is an autoimmune disease caused by the immune‐mediated destruction of
insulin‐producing pancreatic β cells. In recent years, the incidence of type 1 diabetes …
insulin‐producing pancreatic β cells. In recent years, the incidence of type 1 diabetes …
Human mesenchymal stem cells and derived extracellular vesicles induce regulatory dendritic cells in type 1 diabetic patients
E Favaro, A Carpanetto, C Caorsi, M Giovarelli… - Diabetologia, 2016 - Springer
Aims/hypothesis Mesenchymal stem cells (MSCs) can exert an immunosuppressive effect
on any component of the immune system, including dendritic cells (DCs), by direct contact …
on any component of the immune system, including dendritic cells (DCs), by direct contact …
Immunomodulation by subcutaneously injected methacrylic acid-based hydrogels and tolerogenic dendritic cells in a mouse model of autoimmune diabetes
SM Kinney, K Ortaleza, SY Won, BJM Licht, MV Sefton - Biomaterials, 2023 - Elsevier
Type 1 diabetes is an autoimmune disease associated with the destruction of insulin-
producing β cells. Immunotherapies are being developed to mitigate autoimmune diabetes …
producing β cells. Immunotherapies are being developed to mitigate autoimmune diabetes …
Tolerogenic dendritic cells for reprogramming of lymphocyte responses in autoimmune diseases
P García-González, G Ubilla-Olguín, D Catalán… - Autoimmunity …, 2016 - Elsevier
Dendritic cells (DCs) control immune responses by driving potent inflammatory actions
against external and internal threats while generating tolerance to self and harmless …
against external and internal threats while generating tolerance to self and harmless …
Harnessing the power of regulatory T‐cells to control autoimmune diabetes: overview and perspective
H Yu, R Paiva, RA Flavell - Immunology, 2018 - Wiley Online Library
Summary Type 1 diabetes (T1D) is a T‐cell‐mediated autoimmune disease resulting in islet
β‐cell destruction, hypoinsulinaemia and severely altered glucose homeostasis. Although …
β‐cell destruction, hypoinsulinaemia and severely altered glucose homeostasis. Although …
Induction of antigen-specific immune tolerance using biodegradable nanoparticles containing antigen and dexamethasone
SH Kim, JH Moon, SU Jeong, HH Jung… - International journal …, 2019 - Taylor & Francis
Purpose Dexamethasone (Dex) has long been used as a potent immunosuppressive agent
in the treatment of inflammatory and autoimmune diseases, despite serious side effects. In …
in the treatment of inflammatory and autoimmune diseases, despite serious side effects. In …
Cell therapy for type 1 diabetes
ABSTRACT Introduction Type 1 diabetes (T1D) is a lifelong condition resulting from
autoimmune destruction of insulin-producing β-cells. Islet or whole-pancreas transplantation …
autoimmune destruction of insulin-producing β-cells. Islet or whole-pancreas transplantation …
GPR41 deficiency aggravates type 1 diabetes in streptozotocin-treated mice by promoting dendritic cell maturation
J Li, M Zhang, Z Zhang, X Pan, L Pan… - Acta Pharmacologica …, 2024 - nature.com
Disturbances in intestinal immune homeostasis predispose susceptible individuals to type 1
diabetes (T1D). G-protein-coupled receptor 41 (GPR41) is a receptor for short-chain fatty …
diabetes (T1D). G-protein-coupled receptor 41 (GPR41) is a receptor for short-chain fatty …
[PDF][PDF] Generation, Characteristics and Clinical Trials of Ex Vivo Generated Tolerogenic Dendritic Cells
SH Kim, HH Jung, CK Lee - Yonsei medical journal, 2018 - synapse.koreamed.org
Dendritic cells (DCs) play a key role not only in the initiation of primary immune responses,
but also in the development and maintenance of immune tolerance. Numerous protocols …
but also in the development and maintenance of immune tolerance. Numerous protocols …