Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

One of the most significant conceptual advances in immunology in recent history is the
recognition that signals from the innate immune system are required for induction of …

As a key component of the inflammasome, NLRP3 is a critical intracellular danger sensor
emerging as an important clinical target in inflammatory diseases. However, little is known …

Since the identification and characterization of gasdermin (GSDM) D as the main effector of
inflammatory regulated cell death (or pyroptosis), literature on the GSDM family of pore …

Inflammasomes are supramolecular platforms that organize in response to various damage-
associated molecular patterns and pathogen-associated molecular patterns. Upon …

Background Circadian disturbance is a common nonmotor complaint in Parkinson's disease
(PD). The molecular basis underlying circadian rhythm in PD is poorly understood …

Cell division and cell death are fundamental processes governing growth and development
across the tree of life. This relationship represents an evolutionary link between cell cycle …

The spatiotemporal regulation of inflammasome activation remains unclear. To examine the
mechanism underlying the assembly and regulation of the inflammasome response, here …

Inflammasome sensors detect pathogen-and danger-associated molecular patterns and
promote inflammation and pyroptosis. NLRP1 was the first inflammasome sensor to be …

Guanylate-binding proteins (GBPs) are a family of intracellular proteins which have diverse
biological functions, including pathogen sensing and host defense against infectious …