A nucleator arms race: cellular control of actin assembly
For over a decade, the actin-related protein 2/3 (ARP2/3) complex, a handful of nucleation-
promoting factors and formins were the only molecules known to directly nucleate actin …
promoting factors and formins were the only molecules known to directly nucleate actin …
Cytokinesis, ploidy and aneuploidy
B Lacroix, AS Maddox - The Journal of pathology, 2012 - Wiley Online Library
Cytokinesis is the last step of cell division that physically separates the daughter cells. As
such, it ensures the proper inheritance of both nuclear and cytoplasmic contents …
such, it ensures the proper inheritance of both nuclear and cytoplasmic contents …
Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome
A Aiuti, L Biasco, S Scaramuzza, F Ferrua, MP Cicalese… - Science, 2013 - science.org
Introduction Wiskott-Aldrich syndrome (WAS) is a primary immunodeficiency characterized
by eczema, thrombocytopenia, infections, and a high risk of develo** autoimmunity and …
by eczema, thrombocytopenia, infections, and a high risk of develo** autoimmunity and …
Gene therapy for Wiskott-Aldrich syndrome—long-term efficacy and genotoxicity
Wiskott-Aldrich syndrome (WAS) is characterized by microthrombocytopenia,
immunodeficiency, autoimmunity, and susceptibility to malignancies. In our hematopoietic …
immunodeficiency, autoimmunity, and susceptibility to malignancies. In our hematopoietic …
Lentiviral haemopoietic stem/progenitor cell gene therapy for treatment of Wiskott-Aldrich syndrome: interim results of a non-randomised, open-label, phase 1/2 …
F Ferrua, MP Cicalese, S Galimberti… - The Lancet …, 2019 - thelancet.com
Summary Background Wiskott-Aldrich syndrome is a rare, life-threatening, X-linked primary
immunodeficiency characterised by microthrombocytopenia, infections, eczema …
immunodeficiency characterised by microthrombocytopenia, infections, eczema …
Relationship between paediatric CT scans and subsequent risk of leukaemia and brain tumours: assessment of the impact of underlying conditions
AB De Gonzalez, JA Salotti, K McHugh, MP Little… - British journal of …, 2016 - nature.com
Background: We previously reported evidence of a dose–response relationship between
ionising-radiation exposure from paediatric computed tomography (CT) scans and the risk of …
ionising-radiation exposure from paediatric computed tomography (CT) scans and the risk of …
Stem-cell gene therapy for the Wiskott–Aldrich syndrome
K Boztug, M Schmidt, A Schwarzer… - … England Journal of …, 2010 - Mass Medical Soc
The Wiskott–Aldrich syndrome (WAS) is an X-linked recessive primary immunodeficiency
disorder associated with thrombocytopenia, eczema, and autoimmunity. We treated two …
disorder associated with thrombocytopenia, eczema, and autoimmunity. We treated two …
Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease
Abstract Human actin-related protein 2/3 complex (Arp2/3), required for actin filament
branching, has two ARPC1 component isoforms, with ARPC1B prominently expressed in …
branching, has two ARPC1 component isoforms, with ARPC1B prominently expressed in …
Long-term outcome and lineage-specific chimerism in 194 patients with Wiskott-Aldrich syndrome treated by hematopoietic cell transplantation in the period 1980 …
D Moratto, S Giliani, C Bonfim… - Blood, The Journal …, 2011 - ashpublications.org
In this retrospective collaborative study, we have analyzed long-term outcome and donor
cell engraftment in 194 patients with Wiskott-Aldrich syndrome (WAS) who have been …
cell engraftment in 194 patients with Wiskott-Aldrich syndrome (WAS) who have been …
T-cell defects in patients with ARPC1B germline mutations account for combined immunodeficiency
ARPC1B is a key factor for the assembly and maintenance of the ARP2/3 complex that is
involved in actin branching from an existing filament. Germline biallelic mutations in …
involved in actin branching from an existing filament. Germline biallelic mutations in …