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Small molecules in the treatment of COVID-19
S Lei, X Chen, J Wu, X Duan, K Men - Signal transduction and targeted …, 2022 - nature.com
The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …
societies and economies. Until now, effective therapeutics against COVID-19 are in high …
[HTML][HTML] A review of the antibacterial, fungicidal and antiviral properties of selenium nanoparticles
DA Serov, VV Khabatova, V Vodeneev, R Li… - Materials, 2023 - mdpi.com
The resistance of microorganisms to antimicrobial drugs is an important problem worldwide.
To solve this problem, active searches for antimicrobial components, approaches and …
To solve this problem, active searches for antimicrobial components, approaches and …
Real-world effectiveness of molnupiravir and nirmatrelvir plus ritonavir against mortality, hospitalisation, and in-hospital outcomes among community-dwelling …
Background Little is known about the real-world effectiveness of oral antivirals against the
SARS-CoV-2 omicron (B. 1.1. 529) variant. We aimed to assess the clinical effectiveness of …
SARS-CoV-2 omicron (B. 1.1. 529) variant. We aimed to assess the clinical effectiveness of …
Real-world effectiveness of early molnupiravir or nirmatrelvir–ritonavir in hospitalised patients with COVID-19 without supplemental oxygen requirement on admission …
Background Data on the effectiveness of oral antivirals in patients with mild-to-moderate
COVID-19 are urgently needed. This retrospective cohort study aimed to evaluate the …
COVID-19 are urgently needed. This retrospective cohort study aimed to evaluate the …
[HTML][HTML] Feline infectious peritonitis: European advisory board on cat diseases guidelines
S Tasker, DD Addie, H Egberink, R Hofmann-Lehmann… - Viruses, 2023 - mdpi.com
Feline coronavirus (FCoV) is a ubiquitous RNA virus of cats, which is transmitted faeco-
orally. In these guidelines, the European Advisory Board on Cat Diseases (ABCD) presents …
orally. In these guidelines, the European Advisory Board on Cat Diseases (ABCD) presents …
Nitazoxanide and COVID-19: a review
Abstract Coronavirus disease 2019 (COVID-19) is a current global illness triggered by
severe acute respiratory coronavirus 2 (SARS-CoV-2) leading to acute viral pneumonia …
severe acute respiratory coronavirus 2 (SARS-CoV-2) leading to acute viral pneumonia …
A retrospective cohort study on early antibiotic use in vaccinated and unvaccinated COVID‐19 patients
The bacteriophage behavior of SARS‐CoV‐2 during the acute and post‐COVID‐19 phases
appears to be an important factor in the development of the disease. The early use of …
appears to be an important factor in the development of the disease. The early use of …
Molnupiravir: A versatile prodrug against SARS-CoV-2 variants
The nucleoside analog β-DN 4-hydroxycytidine is the active metabolite of the prodrug
molnupiravir and is accepted as an efficient drug against COVID-19. Molnupiravir targets the …
molnupiravir and is accepted as an efficient drug against COVID-19. Molnupiravir targets the …
[HTML][HTML] Medicinal chemistry strategies towards the development of non-covalent SARS-CoV-2 Mpro inhibitors
L Song, S Gao, B Ye, M Yang, Y Cheng, D Kang… - … Pharmaceutica Sinica B, 2024 - Elsevier
The main protease (M pro) of SARS-CoV-2 is an attractive target in anti-COVID-19 therapy
for its high conservation and major role in the virus life cycle. The covalent M pro inhibitor …
for its high conservation and major role in the virus life cycle. The covalent M pro inhibitor …
[HTML][HTML] SARS-CoV-2 proteases Mpro and PLpro: Design of inhibitors with predicted high potency and low mammalian toxicity using artificial neural networks, ligand …
RS Tumskiy, AV Tumskaia, IN Klochkova… - Computers in Biology …, 2023 - Elsevier
The main (Mpro) and papain-like (PLpro) proteases are highly conserved viral proteins
essential for replication of the COVID-19 virus, SARS-COV-2. Therefore, a logical plan for …
essential for replication of the COVID-19 virus, SARS-COV-2. Therefore, a logical plan for …