The escalating prevalence of cancer on a global scale, coupled with the inadequacies of
present-day therapies and the emergence of drug-resistant cancer strains, has necessitated …

An emerging vision for toxicity testing in the 21st century foresees in vitro assays assuming
the leading role in testing for chemical hazards, including testing for carcinogenicity. Toxicity …

The presence of phosphorylated histone H2AX (γ-H2AX) is associated with the local
activation of DNA-damage repair pathways. Although γ-H2AX deregulation in cancer has …

Background High-content screening (HCS) is a pre-clinical approach for the assessment of
drug efficacy. On modern platforms, it involves fluorescent image capture using three …

Abstract High-resolution three-dimensional (3-D) microscopy combined with multiplexing of
fluorescent labels allows high-content analysis of large numbers of cell nuclei. The full …

This study reports on probing the utility of in situ chromatin texture features such as nuclear
DNA methylation and chromatin condensation patterns—visualized by fluorescent staining …

Pharmacoepigenomics is an emerging tool which complements pharmacogenetics in
personalized treatment. While pharmacogenetics refers to genetic variation in …

Cell-surface markers and transcription factors are being used in the assessment of stem cell
fate and therapeutic safety, but display significant variability in stem cell cultures. We …

Liver cancer (hepatocellular carcinoma or HCC) is a major cancer worldwide. Research in
this field is needed to identify biomarkers that can be used for early detection of the disease …

Background Global DNA hypomethylation is a prominent feature of cancer cells including
lung cancer, that has not been widely explored towards cancer diagnosis. In this study we …