Intercalated cells (ICs) are found in the connecting tubule and the collecting duct. Of the
three IC subtypes identified, type B intercalated cells are one of the best characterized and …

Renal tubular acidosis (RTA) comprises a group of disorders in which excretion of hydrogen
ions or reabsorption of filtered HCO 3 is impaired, leading to chronic metabolic acidosis with …

During development, distinct progenitors contribute to the nephrons versus the ureteric
epithelium of the kidney. Indeed, previous human pluripotent stem-cell-derived models of …

Cardiovascular diseases (CVDs), including all types of disorders related to the heart or
blood vessels, are the major public health problems and the leading causes of mortality …

Bardet–Biedl syndrome (BBS) is a rare pleiotropic inherited disorder known as a ciliopathy.
Kidney disease is a cardinal clinical feature; however, it is one of the less investigated traits …

Background MicroRNAs (miRNAs), formed by cleavage of pre-microRNA by the
endoribonuclease Dicer, are critical modulators of cell function by post-transcriptionally …

Although most nephron segments contain one type of epithelial cell, the collecting ducts
consists of at least two: intercalated (IC) and principal (PC) cells, which regulate acid-base …

Background: Distal renal tubular acidosis (dRTA) is characterized by an impairment of the
urinary acidification process in the distal nephron. Complete or incomplete metabolic …

The collecting duct is the predominant nephron site of prorenin and prorenin receptor (PRR)
expression. We previously demonstrated that the collecting duct PRR regulates epithelial …

Potassium depletion affects AQP2 expression and the cellular composition of the kidney
collecting duct. This, in turn, contributes to the development of a secondary form of …