[HTML][HTML] Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease

N Hirokawa, S Niwa, Y Tanaka - Neuron, 2010 - cell.com
The kinesin, dynein, and myosin superfamily molecular motors have fundamental roles in
neuronal function, plasticity, morphogenesis, and survival by transporting cargos such as …

Intracellular transport and kinesin superfamily proteins, KIFs: structure, function, and dynamics

N Hirokawa, Y Noda - Physiological reviews, 2008 - journals.physiology.org
Various molecular cell biology and molecular genetic approaches have indicated significant
roles for kinesin superfamily proteins (KIFs) in intracellular transport and have shown that …

Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility

J Barc, R Tadros, C Glinge, DY Chiang, M Jouni… - Nature …, 2022 - nature.com
Brugada syndrome (BrS) is a cardiac arrhythmia disorder associated with sudden death in
young adults. With the exception of SCN5A, encoding the cardiac sodium channel NaV1. 5 …

Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity

J Jaworski, LC Kapitein, SM Gouveia, BR Dortland… - Neuron, 2009 - cell.com
Dendritic spines are the major sites of excitatory synaptic input, and their morphological
changes have been linked to learning and memory processes. Here, we report that growing …

Localization and targeting of voltage-dependent ion channels in mammalian central neurons

H Vacher, DP Mohapatra… - Physiological …, 2008 - journals.physiology.org
The intrinsic electrical properties and the synaptic input-output relationships of neurons are
governed by the action of voltage-dependent ion channels. The localization of specific …

Growth cone travel in space and time: the cellular ensemble of cytoskeleton, adhesion, and membrane

EA Vitriol, JQ Zheng - Neuron, 2012 - cell.com
Growth cones, found at the tip of axonal projections, are the sensory and motile organelles
of develo** neurons that enable axon pathfinding and target recognition for precise wiring …

Voltage‐gated potassium channels and the diversity of electrical signalling

LY Jan, YN Jan - The Journal of physiology, 2012 - Wiley Online Library
Abstract Since Hodgkin and Huxley discovered the potassium current that underlies the
falling phase of action potentials in the squid giant axon, the diversity of voltage‐gated …

Single molecule imaging reveals differences in microtubule track selection between Kinesin motors

D Cai, DP McEwen, JR Martens, E Meyhofer… - PLoS …, 2009 - journals.plos.org
Cells generate diverse microtubule populations by polymerization of a common α/β-tubulin
building block. How microtubule associated proteins translate microtubule heterogeneity …

Ancillary Subunits Associated With Voltage-Dependent K+ Channels

O Pongs, JR Schwarz - Physiological reviews, 2010 - journals.physiology.org
Since the first discovery of Kvβ-subunits more than 15 years ago, many more ancillary Kv
channel subunits were characterized, for example, KChIPs, KCNEs, and BKβ-subunits. The …

The cellular mechanisms that maintain neuronal polarity

M Bentley, G Banker - Nature Reviews Neuroscience, 2016 - nature.com
As polarized cells, neurons maintain different sets of resident plasma membrane proteins in
their axons and dendrites, which is consistent with the different roles that these neurites …