[HTML][HTML] Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease
The kinesin, dynein, and myosin superfamily molecular motors have fundamental roles in
neuronal function, plasticity, morphogenesis, and survival by transporting cargos such as …
neuronal function, plasticity, morphogenesis, and survival by transporting cargos such as …
Intracellular transport and kinesin superfamily proteins, KIFs: structure, function, and dynamics
N Hirokawa, Y Noda - Physiological reviews, 2008 - journals.physiology.org
Various molecular cell biology and molecular genetic approaches have indicated significant
roles for kinesin superfamily proteins (KIFs) in intracellular transport and have shown that …
roles for kinesin superfamily proteins (KIFs) in intracellular transport and have shown that …
Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility
Brugada syndrome (BrS) is a cardiac arrhythmia disorder associated with sudden death in
young adults. With the exception of SCN5A, encoding the cardiac sodium channel NaV1. 5 …
young adults. With the exception of SCN5A, encoding the cardiac sodium channel NaV1. 5 …
Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity
Dendritic spines are the major sites of excitatory synaptic input, and their morphological
changes have been linked to learning and memory processes. Here, we report that growing …
changes have been linked to learning and memory processes. Here, we report that growing …
Localization and targeting of voltage-dependent ion channels in mammalian central neurons
The intrinsic electrical properties and the synaptic input-output relationships of neurons are
governed by the action of voltage-dependent ion channels. The localization of specific …
governed by the action of voltage-dependent ion channels. The localization of specific …
Growth cone travel in space and time: the cellular ensemble of cytoskeleton, adhesion, and membrane
Growth cones, found at the tip of axonal projections, are the sensory and motile organelles
of develo** neurons that enable axon pathfinding and target recognition for precise wiring …
of develo** neurons that enable axon pathfinding and target recognition for precise wiring …
Voltage‐gated potassium channels and the diversity of electrical signalling
LY Jan, YN Jan - The Journal of physiology, 2012 - Wiley Online Library
Abstract Since Hodgkin and Huxley discovered the potassium current that underlies the
falling phase of action potentials in the squid giant axon, the diversity of voltage‐gated …
falling phase of action potentials in the squid giant axon, the diversity of voltage‐gated …
Single molecule imaging reveals differences in microtubule track selection between Kinesin motors
Cells generate diverse microtubule populations by polymerization of a common α/β-tubulin
building block. How microtubule associated proteins translate microtubule heterogeneity …
building block. How microtubule associated proteins translate microtubule heterogeneity …
Ancillary Subunits Associated With Voltage-Dependent K+ Channels
O Pongs, JR Schwarz - Physiological reviews, 2010 - journals.physiology.org
Since the first discovery of Kvβ-subunits more than 15 years ago, many more ancillary Kv
channel subunits were characterized, for example, KChIPs, KCNEs, and BKβ-subunits. The …
channel subunits were characterized, for example, KChIPs, KCNEs, and BKβ-subunits. The …
The cellular mechanisms that maintain neuronal polarity
M Bentley, G Banker - Nature Reviews Neuroscience, 2016 - nature.com
As polarized cells, neurons maintain different sets of resident plasma membrane proteins in
their axons and dendrites, which is consistent with the different roles that these neurites …
their axons and dendrites, which is consistent with the different roles that these neurites …