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Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer
Cancer is the second leading cause of human death globally. PI3K/Akt/mTOR signaling is
one of the most frequently dysregulated signaling pathways observed in cancer patients that …
one of the most frequently dysregulated signaling pathways observed in cancer patients that …
Drug resistance in Plasmodium
A marked decrease in malaria-related deaths worldwide has been attributed to the
administration of effective antimalarials against Plasmodium falciparum, in particular …
administration of effective antimalarials against Plasmodium falciparum, in particular …
[HTML][HTML] Is Alzheimer's disease a type 3 diabetes? A critical appraisal
Recently researchers proposed the term 'Type-3-Diabetes' for Alzheimer's disease (ad)
because of the shared molecular and cellular features among Type-1-Diabetes, Type-2 …
because of the shared molecular and cellular features among Type-1-Diabetes, Type-2 …
Determinants and clinical implications of chromosomal instability in cancer
Aberrant chromosomal architecture, ranging from small insertions or deletions to large
chromosomal alterations, is one of the most common characteristics of cancer genomes …
chromosomal alterations, is one of the most common characteristics of cancer genomes …
Neuronal lipid metabolism: multiple pathways driving functional outcomes in health and disease
Lipids are a fundamental class of organic molecules implicated in a wide range of biological
processes related to their structural diversity, and based on this can be broadly classified …
processes related to their structural diversity, and based on this can be broadly classified …
PI3K and cancer: lessons, challenges and opportunities
The central role of phosphoinositide 3-kinase (PI3K) activation in tumour cell biology has
prompted a sizeable effort to target PI3K and/or downstream kinases such as AKT and …
prompted a sizeable effort to target PI3K and/or downstream kinases such as AKT and …
Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism
Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that
regulate lipid biosynthesis and adipogenesis by controlling the expression of several …
regulate lipid biosynthesis and adipogenesis by controlling the expression of several …
Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development
An increased rate of lipid synthesis in cancerous tissues has long been recognised as an
important aspect of the rewired metabolism of transformed cells. However, the contribution of …
important aspect of the rewired metabolism of transformed cells. However, the contribution of …
The emerging mechanisms of isoform-specific PI3K signalling
Abstract Phosphoinositide 3-kinases (PI3Ks) function early in intracellular signal
transduction pathways and affect many biological functions. A further level of complexity …
transduction pathways and affect many biological functions. A further level of complexity …
Endothelial dysfunction in obesity
Chronic inflammatory state in obesity causes dysregulation of the endocrine and paracrine
actions of adipocyte-derived factors, which disrupt vascular homeostasis and contribute to …
actions of adipocyte-derived factors, which disrupt vascular homeostasis and contribute to …