Intratumoral microbiota: roles in cancer initiation, development and therapeutic efficacy

L Yang, A Li, Y Wang, Y Zhang - Signal Transduction and Targeted …, 2023‏ - nature.com
Microorganisms, including bacteria, viruses, fungi, and other eukaryotes, play critical roles in
human health. An altered microbiome can be associated with complex diseases …

Exploiting bacteria for cancer immunotherapy

SY Kwon, H Thi-Thu Ngo, J Son, Y Hong… - Nature Reviews Clinical …, 2024‏ - nature.com
Immunotherapy has revolutionized the treatment of cancer but continues to be constrained
by limited response rates, acquired resistance, toxicities and high costs, which necessitates …

Bacteria loaded with glucose polymer and photosensitive ICG silicon-nanoparticles for glioblastoma photothermal immunotherapy

R Sun, M Liu, J Lu, B Chu, Y Yang, B Song… - Nature …, 2022‏ - nature.com
Bacteria can bypass the blood-brain barrier (BBB), suggesting the possibility of employment
of bacteria for combating central nervous system diseases. Herein, we develop a bacteria …

Bacteria-cancer interactions: bacteria-based cancer therapy

MTQ Duong, Y Qin, SH You, JJ Min - Experimental & molecular …, 2019‏ - nature.com
Recent advances in cancer therapeutics, such as targeted therapy and immunotherapy,
have raised the hope for cures for many cancer types. However, there are still ongoing …

Tumour-targeting bacteria engineered to fight cancer

S Zhou, C Gravekamp, D Bermudes, K Liu - Nature Reviews Cancer, 2018‏ - nature.com
Recent advances in targeted therapy and immunotherapy have once again raised the hope
that a cure might be within reach for many cancer types. Yet, most late-stage cancers are …

[PDF][PDF] Bacteria‐based cancer immunotherapy

X Huang, J Pan, F Xu, B Shao, Y Wang… - Advanced …, 2021‏ - Wiley Online Library
In the past decade, bacteria‐based cancer immunotherapy has attracted much attention in
the academic circle due to its unique mechanism and abundant applications in triggering the …

The role of TLRs in anti-cancer immunity and tumor rejection

Z Urban-Wojciuk, MM Khan, BL Oyler… - Frontiers in …, 2019‏ - frontiersin.org
In recent years, a lot of scientific interest has focused on cancer immunotherapy. Although
chronic inflammation has been described as one of the hallmarks of cancer, acute …

Therapeutic bacteria to combat cancer; current advances, challenges, and opportunities

M Sedighi, A Zahedi Bialvaei, MR Hamblin… - Cancer …, 2019‏ - Wiley Online Library
Successful treatment of cancer remains a challenge, due to the unique pathophysiology of
solid tumors, and the predictable emergence of resistance. Traditional methods for cancer …

Bacteria-triggered tumor-specific thrombosis to enable potent photothermal immunotherapy of cancer

X Yi, H Zhou, Y Chao, S **ong, J Zhong, Z Chai… - Science …, 2020‏ - science.org
We discovered that attenuated Salmonella after intravenous injection would proliferate
within various types of solid tumors but show rapid clearance in normal organs, without …

Aptamer-assisted tumor localization of bacteria for enhanced biotherapy

Z Geng, Z Cao, R Liu, K Liu, J Liu, W Tan - Nature Communications, 2021‏ - nature.com
Despite bacterial-mediated biotherapies have been widely explored for treating different
types of cancer, their implementation has been restricted by low treatment efficacy, due …