Factors affecting the performance of HRP2-based malaria rapid diagnostic tests
The recent COVID-19 pandemic has profoundly impacted global malaria elimination
programs, resulting in a sharp increase in malaria morbidity and mortality. To reduce this …
programs, resulting in a sharp increase in malaria morbidity and mortality. To reduce this …
Plasmodium falciparum is evolving to escape malaria rapid diagnostic tests in Ethiopia
SM Feleke, EN Reichert, H Mohammed… - Nature …, 2021 - nature.com
In Africa, most rapid diagnostic tests (RDTs) for falciparum malaria recognize histidine-rich
protein 2 antigen. Plasmodium falciparum parasites lacking histidine-rich protein 2 (pfhrp2) …
protein 2 antigen. Plasmodium falciparum parasites lacking histidine-rich protein 2 (pfhrp2) …
Smartphone-based DNA diagnostics for malaria detection using deep learning for local decision support and blockchain technology for security
In infectious disease diagnosis, results need to be communicated rapidly to healthcare
professionals once testing has been completed so that care pathways can be implemented …
professionals once testing has been completed so that care pathways can be implemented …
Malaria diagnosis in non-endemic settings: The European experience in the last 22 years
A Calderaro, S Montecchini, M Buttrini, G Piccolo… - Microorganisms, 2021 - mdpi.com
Accurate, prompt, and reliable tools for the diagnosis of malaria are crucial for tracking the
successes or drawbacks of control and elimination efforts, and for future programs aimed at …
successes or drawbacks of control and elimination efforts, and for future programs aimed at …
High-throughput Plasmodium falciparum hrp2 and hrp3 gene deletion ty** by digital PCR to monitor malaria rapid diagnostic test efficacy
Most rapid diagnostic tests for Plasmodium falciparum malaria target the Histidine-Rich
Proteins 2 and 3 (HRP2 and HRP3). Deletions of the hrp2 and hrp3 genes result in false …
Proteins 2 and 3 (HRP2 and HRP3). Deletions of the hrp2 and hrp3 genes result in false …
Detection of high prevalence of Plasmodium falciparum histidine-rich protein 2/3 gene deletions in Assosa zone, Ethiopia: implication for malaria diagnosis
GS Alemayehu, K Blackburn, K Lopez… - Malaria journal, 2021 - Springer
Abstract Background Rapid diagnostic tests (RDTs) targeting histidine rich protein 2 (HRP2)
are widely used for diagnosis of Plasmodium falciparum infections. Besides PfHRP2, the …
are widely used for diagnosis of Plasmodium falciparum infections. Besides PfHRP2, the …
Analysis of false-negative rapid diagnostic tests for symptomatic malaria in the Democratic Republic of the Congo
The majority of Plasmodium falciparum malaria diagnoses in Africa are made using rapid
diagnostic tests (RDTs) that detect histidine-rich protein 2. Increasing reports of false …
diagnostic tests (RDTs) that detect histidine-rich protein 2. Increasing reports of false …
Flexible and cost-effective genomic surveillance of P. falciparum malaria with targeted nanopore sequencing
M de Cesare, M Mwenda, AE Jeffreys, J Chirwa… - Nature …, 2024 - nature.com
Genomic surveillance of Plasmodium falciparum malaria can provide policy-relevant
information about antimalarial drug resistance, diagnostic test failure, and the evolution of …
information about antimalarial drug resistance, diagnostic test failure, and the evolution of …
Epidemiology of mutant Plasmodium falciparum parasites lacking histidine-rich protein 2/3 genes in Eritrea 2 years after switching from HRP2-based RDTs
Eritrea was the first African country to complete a nationwide switch in 2016 away from
HRP2-based RDTs due to high rates of false-negative RDT results caused by Plasmodium …
HRP2-based RDTs due to high rates of false-negative RDT results caused by Plasmodium …
Malaria rapid tests, febrile illness management, and child mortality across sub-Saharan African countries
Importance A prompt malaria diagnosis is crucial for the management of children with febrile
illness in sub-Saharan African countries, where malaria remains a leading cause of mortality …
illness in sub-Saharan African countries, where malaria remains a leading cause of mortality …