BACKGROUND Tertiary lymphoid structures (TLSs) are organized aggregates of immune
cells that form postnatally in nonlymphoid tissues. TLSs are not found under physiological …

The lungs are constantly exposed to inhaled debris, allergens, pollutants, commensal or
pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive …

Lymph nodes (LNs) are strategically positioned at dedicated sites throughout the body to
facilitate rapid and efficient immunity. Central to the structural integrity and framework of LNs …

Ectopic lymphoid-like structures often develop at sites of inflammation where they influence
the course of infection, autoimmune disease, cancer and transplant rejection. These …

The characterization of the microenvironment of human tumors led to the description of
tertiary lymphoid structures (TLS) characterized by mature dendritic cells in a T‐cell zone …

Tertiary lymphoid structures (TLSs) are defined as lymphoid aggregates formed in non-
hematopoietic organs under pathological conditions. Similar to secondary lymphoid organs …

Tertiary lymphoid structures (TLS) are ectopic lymphoid formations found in inflamed,
infected, or tumoral tissues. They exhibit all the characteristics of structures in the lymph …

Tumor-associated tertiary lymphoid structures (TA-TLS) are associated with enhanced
patient survival and responsiveness to cancer therapies, but the mechanisms underlying …

Lymphoid follicles (LFs) are responsible for generation of adaptive immune responses in
secondary lymphoid organs and form ectopically during chronic inflammation. A human …

Tumor-infiltrating T cells, particularly CD45RO+ CD8+ memory T cells, confer a positive
prognostic value in human cancers. However, the mechanisms that promote a protective T …