This review article provides an historical perspective on some of the major research
advances of relevance to ruminant livestock gastrointestinal nematode control over the last …

Dirofilaria immitis, also known as heartworm, is a major parasitic threat for dogs and cats
around the world. Because of its impact on the health and welfare of companion animals …

Like other pathogens, parasitic helminths can rapidly evolve resistance to drug treatment.
Understanding the genetic basis of anthelmintic drug resistance in parasitic nematodes is …

Haemonchus contortus is a globally distributed and economically important gastrointestinal
pathogen of small ruminants and has become a key nematode model for studying …

Parasitic nematodes infect almost all forms of life. In the human context, parasites are one of
the major causative factors for physical and intellectual growth retardation in the develo** …

Protein kinases are highly tractable targets for drug discovery. However, the biological
function and therapeutic potential of the majority of the 500+ human protein kinases remains …

Highlights•Gastrointestinal nematodes are resistant to available anthelmintics.•No new
anthelmintic on the market for several years.•A target-based approach, drug repurposing or …

Parasitic worms cause very significant diseases in animals and humans worldwide, and
their control is critical to enhance health, well-being and productivity. Due to widespread …

Parasitic helminths infect over 1 billion people worldwide, while current treatments rely on a
limited arsenal of drugs. To expedite drug discovery, we screened a small-molecule library …

Parasitic nematodes infect hundreds of millions of people and farmed livestock. Further,
plant parasitic nematodes result in major crop damage. The pipeline of therapeutic …