The conceptual evolution of nicotinamide adenine dinucleotide (NAD+) from being seen as
a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and …

L-Tryptophan is an essential amino acid required for protein synthesis. It undergoes an
extensive and complex metabolism along several pathways, resulting in many bioactive …

Despite intensive preventive cardiovascular disease (CVD) efforts, substantial residual CVD
risk remains even for individuals receiving all guideline-recommended interventions. Niacin …

Nicotinamide adenine dinucleotide (NAD+) is a co-substrate for several enzymes, including
the sirtuin family of NAD+-dependent protein deacylases. Beneficial effects of increased …

Recent advances highlight a pivotal role for cellular metabolism in programming immune
responses. Here, we demonstrate that cell-autonomous generation of nicotinamide adenine …

Acute kidney injury (AKI) is a global public health concern associated with high morbidity
and mortality. Although advances in medical management have improved the in-hospital …

The importance of the kynurenine pathway in normal immune system function has led to an
appreciation of its possible contribution to autoimmune disorders such as rheumatoid …

The unique physicochemical properties and fascinating bioisosterism of tetrazole scaffolds
have received significant attention in medicinal chemistry. We report recent efforts using …

Age-related alterations in endothelium and the resulting vascular dysfunction critically
contribute to a range of pathological conditions associated with old age. To develop …

The essential amino acid L-tryptophan (Trp) appears to play an important role in aging by
acting as a general regulator of protein homeostasis. The major route of Trp degradation, the …