Thiazole ring—A biologically active scaffold
A Petrou, M Fesatidou, A Geronikaki - Molecules, 2021 - mdpi.com
Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical
applications. Its derivatives have a wide range of biological activities such as antioxidant …
applications. Its derivatives have a wide range of biological activities such as antioxidant …
Thiazoles and thiazolidinones as COX/LOX inhibitors
K Liaras, M Fesatidou, A Geronikaki - Molecules, 2018 - mdpi.com
Inflammation is a natural process that is connected to various conditions and disorders such
as arthritis, psoriasis, cancer, infections, asthma, etc. Based on the fact that cyclooxygenase …
as arthritis, psoriasis, cancer, infections, asthma, etc. Based on the fact that cyclooxygenase …
Computational analysis of eugenol inhibitory activity in lipoxygenase and cyclooxygenase pathways
F Das Chagas Pereira de Andrade, AN Mendes - Scientific reports, 2020 - nature.com
Chronic inflammation is triggered by numerous diseases such as osteoarthritis, Crohn's
disease and cancer. The control of the pro-inflammatory process can prevent, mitigate …
disease and cancer. The control of the pro-inflammatory process can prevent, mitigate …
Fragment merging approach for the design of thiazole/thiazolidine clubbed pyrazoline derivatives as anti-inflammatory agents: Synthesis, biopharmacological …
Fragment merging approach was applied for the design of thiazole/thiazolidinone clubbed
pyrazoline derivatives 5a-e, 6a-c, 7 and 10a-d as dual COX-2 and 5-LOX inhibitors …
pyrazoline derivatives 5a-e, 6a-c, 7 and 10a-d as dual COX-2 and 5-LOX inhibitors …
1, 2, 3-triazole tethered Indole-3-glyoxamide derivatives as multiple inhibitors of 5-LOX, COX-2 & tubulin: Their anti-proliferative & anti-inflammatory activity
To evaluate the role of COX-2 and 5-LOX as dual inhibitors in controlling the cancer cell
proliferation, a set of two series having 42 compounds of 1, 2, 3-Tethered Indole-3 …
proliferation, a set of two series having 42 compounds of 1, 2, 3-Tethered Indole-3 …
New thiazole carboxamide derivatives as COX inhibitors: design, synthesis, anticancer screening, in silico molecular docking, and ADME profile studies
The goal of this work was to create and test a new series of thiazole carboxamide derivatives
for their cyclooxygenase (COX) suppressor and anticancer effects. The compounds were …
for their cyclooxygenase (COX) suppressor and anticancer effects. The compounds were …
Design, synthesis, molecular docking studies and biological evaluation of thiazole carboxamide derivatives as COX inhibitors
Background Nonsteroidal anti-inflammatory drugs (NSAIDs) have been the most commonly
used class of medications worldwide for the last three decades. Objectives This study aimed …
used class of medications worldwide for the last three decades. Objectives This study aimed …
In vitro, in vivo and in silico evaluation of the anti-inflammatory potential of Hyssopus officinalis L. subsp. aristatus (Godr.) Nyman (Lamiaceae)
Ethnopharmacological relevance Medicinal properties of hyssop have been used in
traditional medicine since ancient times, inter alia, in diseases/conditions with an inherent …
traditional medicine since ancient times, inter alia, in diseases/conditions with an inherent …
Benchmarking different docking protocols for predicting the binding poses of ligands complexed with cyclooxygenase enzymes and screening chemical libraries
Introduction: Non-steroidal anti-inflammatory drugs (NSAIDs) constitute an important class of
pharmaceuticals acting on cyclooxygenase COX-1 and COX-2 enzymes. Due to their …
pharmaceuticals acting on cyclooxygenase COX-1 and COX-2 enzymes. Due to their …
[HTML][HTML] Thiazole, triazole, thio-and semicarbazone derivatives-Promising moieties for drug development for the treatment of tuberculosis
Thiazole, triazole, thio and semicarbazones are privileged motifs that act as
pharmacophores in bioactive compounds for various diseases, such as Tuberculosis (TB) …
pharmacophores in bioactive compounds for various diseases, such as Tuberculosis (TB) …