Production of vitamin B2 (riboflavin) by microorganisms: an overview

LA Averianova, LA Balabanova, OM Son… - … in Bioengineering and …, 2020 - frontiersin.org
Riboflavin is a crucial micronutrient that is a precursor to coenzymes flavin mononucleotide
and flavin adenine dinucleotide, and it is required for biochemical reactions in all living cells …

Advances and prospects of Bacillus subtilis cellular factories: from rational design to industrial applications

Y Gu, X Xu, Y Wu, T Niu, Y Liu, J Li, G Du, L Liu - Metabolic engineering, 2018 - Elsevier
Bacillus subtilis is the most characterized gram-positive bacterium that has significant
attributes, such as growing well on cheap carbon sources, possessing clear inherited …

Genetic control of biosynthesis and transport of riboflavin and flavin nucleotides and construction of robust biotechnological producers

CA Abbas, AA Sibirny - Microbiology and molecular biology …, 2011 - journals.asm.org
SUMMARY Riboflavin [7, 8-dimethyl-10-(1′-d-ribityl) isoalloxazine, vitamin B2] is an
obligatory component of human and animal diets, as it serves as the precursor of flavin …

Production of riboflavin and related cofactors by biotechnological processes

S Liu, W Hu, Z Wang, T Chen - Microbial cell factories, 2020 - Springer
Riboflavin (RF) and its active forms, the cofactors flavin mononucleotide (FMN) and flavin
adenine dinucleotide (FAD), have been extensively used in the food, feed and …

Biotechnology of riboflavin

SK Schwechheimer, EY Park, JL Revuelta… - Applied microbiology …, 2016 - Springer
Riboflavin (vitamin B 2) production has shifted from chemical synthesis to exclusive
biotechnological synthesis in less than 15 years. The underlying extraordinary achievement …

Bioproduction of riboflavin: a bright yellow history

JL Revuelta, R Ledesma-Amaro… - Journal of Industrial …, 2017 - academic.oup.com
Riboflavin (vitamin B2) is an essential nutrient for humans and animals that must be
obtained from the diet. To ensure an optimal supply, riboflavin is used on a large scale as …

Develo** Bacillus spp. as a cell factory for production of microbial enzymes and industrially important biochemicals in the context of systems and synthetic biology

L Liu, Y Liu, H Shin, RR Chen, NS Wang, J Li… - Applied Microbiology …, 2013 - Springer
Increasing concerns over limited petroleum resources and associated environmental
problems are motivating the development of efficient cell factories to produce chemicals …

Recent advances in engineering the central carbon metabolism of industrially important bacteria

M Papagianni - Microbial cell factories, 2012 - Springer
This paper gives an overview of the recent advances in engineering the central carbon
metabolism of the industrially important bacteria Escherichia coli, Bacillus subtilis …

Microbial production of riboflavin: biotechnological advances and perspectives

J You, X Pan, C Yang, Y Du, T Osire, T Yang… - Metabolic …, 2021 - Elsevier
Riboflavin is an essential nutrient for humans and animals, and its derivatives flavin
mononucleotide (FMN) and flavin adenine dinucleotide (FAD) are cofactors in the cells …

Engineering Bacillus subtilis for isobutanol production by heterologous Ehrlich pathway construction and the biosynthetic 2-ketoisovalerate precursor pathway …

S Li, J Wen, X Jia - Applied microbiology and biotechnology, 2011 - Springer
In the present work, Bacillus subtilis was engineered as the cell factory for isobutanol
production due to its high tolerance to isobutanol. Initially, an efficient heterologous Ehrlich …