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Immune checkpoint therapy—current perspectives and future directions
Immune checkpoint therapy (ICT) has dramatically altered clinical outcomes for cancer
patients and conferred durable clinical benefits, including cure in a subset of patients …
patients and conferred durable clinical benefits, including cure in a subset of patients …
Gut microbiota in colorectal cancer development and therapy
Colorectal cancer (CRC) is one of the commonest cancers globally. A unique aspect of CRC
is its intimate association with the gut microbiota, which forms an essential part of the tumour …
is its intimate association with the gut microbiota, which forms an essential part of the tumour …
Fecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial
Fecal microbiota transplantation (FMT) represents a potential strategy to overcome
resistance to immune checkpoint inhibitors in patients with refractory melanoma; however …
resistance to immune checkpoint inhibitors in patients with refractory melanoma; however …
[HTML][HTML] Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment
The use of probiotics by cancer patients is increasing, including among those undergoing
immune checkpoint inhibitor (ICI) treatment. Here, we elucidate a critical microbial-host …
immune checkpoint inhibitor (ICI) treatment. Here, we elucidate a critical microbial-host …
Bacteria in cancer initiation, promotion and progression
Cancer cells originate from a series of acquired genetic mutations that can drive their
uncontrolled cell proliferation and immune evasion. Environmental factors, including the …
uncontrolled cell proliferation and immune evasion. Environmental factors, including the …
The dynamic lung microbiome in health and disease
New methods and technologies within the field of lung biology are beginning to shed new
light into the microbial world of the respiratory tract. Long considered to be a sterile …
light into the microbial world of the respiratory tract. Long considered to be a sterile …
Immune checkpoint therapy for solid tumours: clinical dilemmas and future trends
Q Sun, Z Hong, C Zhang, L Wang, Z Han… - Signal transduction and …, 2023 - nature.com
Abstract Immune-checkpoint inhibitors (ICBs), in addition to targeting CTLA-4, PD-1, and PD-
L1, novel targeting LAG-3 drugs have also been approved in clinical application. With the …
L1, novel targeting LAG-3 drugs have also been approved in clinical application. With the …
Faecalibacterium: a bacterial genus with promising human health applications
In humans, many diseases are associated with alterations in gut microbiota, namely
increases or decreases in the abundance of specific bacterial groups. One example is the …
increases or decreases in the abundance of specific bacterial groups. One example is the …
Versatility of bacterial outer membrane vesicles in regulating intestinal homeostasis
X Wang, S Lin, L Wang, Z Cao, M Zhang, Y Zhang… - Science …, 2023 - science.org
Outer membrane vesicles (OMVs) play vital roles in bacterial communication both
intraspecifically and interspecifically. However, extracellular mechanisms of gut microbiota …
intraspecifically and interspecifically. However, extracellular mechanisms of gut microbiota …
Causal relationship between gut microbiota and cancers: a two-sample Mendelian randomisation study
Background Evidence from observational studies and clinical trials suggests that the gut
microbiota is associated with cancer. However, the causal association between gut …
microbiota is associated with cancer. However, the causal association between gut …