B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …

The adaptive immune system recognizes antigens via an immense array of antigen-binding
antibodies and T-cell receptors, the immune repertoire. The interrogation of immune …

Conventional immunization strategies will likely be insufficient for the development of a
broadly neutralizing antibody (bnAb) vaccine for HIV or other difficult pathogens because of …

The emerging SARS-CoV-2 variants, commonly with many mutations in S1 subunit of spike
(S) protein are weakening the efficacy of the current vaccines and antibody therapeutics …

Variation in the antibody response has been linked to differential outcomes in disease, and
suboptimal vaccine and therapeutic responsiveness, the determinants of which have not …

IgA is the dominant immunoglobulin isotype produced in mammals, largely secreted across
the intestinal mucosal surface. Although induction of IgA has been a hallmark feature of …

Next generation sequencing (NGS) of immunoglobulin (Ig) repertoires (Rep-seq) enables
examination of the adaptive immune system at an unprecedented level. Applications include …

B cell response plays a critical role against SARS-CoV-2 infection. However, little is known
about the diversity and frequency of the paired SARS-CoV-2 antigen-specific BCR repertoire …

Effective vaccines inducing lifelong protection against many important infections such as
respiratory syncytial virus (RSV), HIV, influenza virus, and Epstein-Barr virus (EBV) are not …

The adaptive immune system stores invaluable information about current and past immune
responses and may serve as an ultrasensitive biosensor. Given the immune system's critical …