Cancer cells frequently display intrinsic or acquired resistance to chemically diverse
anticancer drugs, limiting therapeutic success. Among the main mechanisms of this …

The primary source of failure of cancer therapies is multidrug resistance (MDR), which can
be caused by different mechanisms, including the overexpression of ABC transporters in …

Cancer remains a leading cause of morbidity and mortality worldwide. Hence, the increase
in cancer cases observed in the elderly population, as well as in children and adolescents …

The kidneys are a pair of important organs that excretes endogenous waste and exogenous
biological agents from the body. Numerous transporters are involved in the excretion …

Determining the target‐bound conformation of a drug‐like molecule is a crucial step in drug
design, as it affects the outcome of virtual screening (VS), and paves the way for hit‐to‐lead …

ATP-binding cassette (ABC) transporters are pivotal for cell detoxification and survival.
Overexpression of ABC transporter in tumor cells lead to chemoresistance through the efflux …

Chalcone, a common chemical scaffold of many naturally occurring compounds, has been
widely used as an effective template for drug discovery due to its broad biological activities …

The human breast cancer resistance protein (BCRP), one of the members of the large ATP
binding cassette (ABC) transporter superfamily, is crucial for resistance against …

Aim: BCRP plays a major role in the efflux of cytotoxic molecules, limiting their
antiproliferative activity. We aimed to design and synthesize new BCRP inhibitors to render …

Reaction of 6-methylchromone-3-carbonitrile (1) with acetylacetone under basic conditions
afforded 3-acetyl-2, 7-dimethyl-5H-chromeno [2, 3-b]-pyridin-5-one (2) which utilized as a …