The surprising discovery that the diatomic gas nitric oxide (NO) is generated by mammalian
cells and serves to regulate a multitude of physiological processes has continued to …

Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

Background Treatment of acute stroke, before a distinction can be made between ischemic
and hemorrhagic types, is challenging. Whether very early blood-pressure control in the …

Stroke is the second highest cause of death globally and a leading cause of disability, with
an increasing incidence in develo** countries. Ischaemic stroke caused by arterial …

Stroke is the leading cause of long term disability in developed countries and one of the top
causes of mortality worldwide. The past decade has seen substantial advances in the …

The optimal blood pressure (BP) management in acute ischaemic stroke (AIS) and acute
intracerebral haemorrhage (ICH) remains controversial. These European Stroke …

Hemorrhagic transformation (HT) is a common complication in patients with acute ischemic
stroke. It occurs when peripheral blood extravasates across a disrupted blood brain barrier …

Importance Cerebral small vessel disease (cSVD) is a common cause of stroke (lacunar
stroke), is the most common cause of vascular cognitive impairment, and impairs mobility …

Background Uncertainty persists over the effects of blood pressure lowering in acute
intracerebral haemorrhage. We aimed to combine individual patient-level data from the two …

Acute ischemic stroke is a serious life‐threatening disease that affects almost 600 million
people each year throughout the world with a mortality of more than 10%, while two‐thirds of …