Glioblastoma multiforme (GBM) is the most common primary brain tumour in adults and
continues to portend poor survival, despite multimodal treatment using surgery and …

Simple Summary Glioblastoma is among the most lethal cancers in humans. Glioblastomas
exhibit a striking heterogeneity, which is maintained by a highly plastic, adaptable …

The response to DNA damage is critical for cellular homeostasis, tumor suppression,
immunity, and gametogenesis. In order to provide an unbiased and global view of the DNA …

Glioblastoma is a universally lethal cancer driven by glioblastoma stem cells (GSC). Here,
we interrogated N 6-methyladenosine (m6A) mRNA modifications in GSCs by methyl RNA …

Glioblastomas harbor diverse cell populations, including rare glioblastoma stem cells
(GSCs) that drive tumorigenesis. To characterize functional diversity within this population …

We test the hypothesis that glioblastoma harbors quiescent cancer stem cells that evade anti-
proliferative therapies. Functional characterization of spontaneous glioblastomas from …

Glioma intratumoral heterogeneity enables adaptation to challenging microenvironments
and contributes to therapeutic resistance. We integrated 914 single-cell DNA methylomes …

Despite its importance in human cancers, including colorectal cancers (CRC), oncogenic
KRAS has been extremely challenging to target therapeutically. To identify potential …

Cancers commonly reprogram translation and metabolism, but little is known about how
these two features coordinate in cancer stem cells. Here we show that glioblastoma stem …

Glioblastomas (GBM) are the most common primary brain tumor with a median survival of 15
months. A population of cells with stem cell properties (glioblastoma stem cells, GSCs) …