The search for noise-induced cochlear synaptopathy in humans: Mission impossible?

N Bramhall, EF Beach, B Epp, CG Le Prell… - Hearing research, 2019 - Elsevier
Animal studies demonstrate that noise exposure can permanently damage the synapses
between inner hair cells and auditory nerve fibers, even when outer hair cells are intact and …

Loud music and leisure noise is a common cause of chronic hearing loss, tinnitus and hyperacusis

M Pienkowski - International journal of environmental research and …, 2021 - mdpi.com
High sound levels capable of permanently damaging the ear are experienced not only in
factories and war zones but in concert halls, nightclubs, sports stadiums, and many other …

Hidden hearing loss: a disorder with multiple etiologies and mechanisms

DC Kohrman, G Wan… - Cold Spring …, 2020 - perspectivesinmedicine.cshlp.org
Hidden hearing loss (HHL), a recently described auditory disorder, has been proposed to
affect auditory neural processing and hearing acuity in subjects with normal audiometric …

[HTML][HTML] Impaired speech perception in noise with a normal audiogram: No evidence for cochlear synaptopathy and no relation to lifetime noise exposure

H Guest, KJ Munro, G Prendergast, RE Millman… - Hearing research, 2018 - Elsevier
In rodents, noise exposure can destroy synapses between inner hair cells and auditory
nerve fibers (“cochlear synaptopathy”) without causing hair cell loss. Noise-induced …

Middle ear muscle reflex and word recognition in “normal-hearing” adults: evidence for cochlear synaptopathy?

AM Mepani, SA Kirk, KE Hancock, K Bennett… - Ear and …, 2020 - journals.lww.com
Objectives: Permanent threshold elevation after noise exposure, ototoxic drugs, or aging is
caused by loss of sensory cells; however, animal studies show that hair cell loss is often …

Electrophysiological markers of cochlear function correlate with hearing-in-noise performance among audiometrically normal subjects

KJ Grant, AM Mepani, P Wu… - Journal of …, 2020 - journals.physiology.org
Hearing loss caused by noise exposure, ototoxic drugs, or aging results from the loss of
sensory cells, as reflected in audiometric threshold elevation. Animal studies show that loss …

Envelope following responses predict speech-in-noise performance in normal-hearing listeners

AM Mepani, S Verhulst, KE Hancock… - Journal of …, 2021 - journals.physiology.org
Permanent threshold elevation after noise exposure or aging is caused by loss of sensory
cells; however, animal studies show that hair cell loss is often preceded by degeneration of …

Effects of lifetime noise exposure on the middle-age human auditory brainstem response, tinnitus and speech-in-noise intelligibility

JT Valderrama, EF Beach, I Yeend, M Sharma… - Hearing research, 2018 - Elsevier
Recent animal studies have shown that the synapses between inner hair cells and the
dendrites of the spiral ganglion cells they innervate are the elements in the cochlea most …

Effects of noise exposure on auditory brainstem response and speech-in-noise tasks: A review of the literature

CG Le Prell - International journal of audiology, 2019 - Taylor & Francis
Objective: Short-term noise exposure that induces transient changes in thresholds has
induced permanent cochlear synaptopathy in multiple species. Here, the literature was …

Working memory and extended high-frequency hearing in adults: Diagnostic predictors of speech-in-noise perception

I Yeend, EF Beach, M Sharma - Ear and Hearing, 2019 - journals.lww.com
Objective: The purpose of this study was to identify the main factors that differentiate
listeners with clinically normal or “near-normal” hearing with regard to their speech-in-noise …