Apolipoprotein E mediates cell resistance to influenza virus infection
P Gao, M Ji, X Liu, X Chen, H Liu, S Li, B Jia, C Li… - Science …, 2022 - science.org
Viruses exploit host cell machinery to support their replication. Defining the cellular proteins
and processes required for a virus during infection is crucial to understanding the …
and processes required for a virus during infection is crucial to understanding the …
Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality
With the rapid global spread of SARS-CoV-2, we have become acutely aware of the
inadequacies of our ability to respond to viral epidemics. Although disrupting the viral life …
inadequacies of our ability to respond to viral epidemics. Although disrupting the viral life …
Applying genome-wide CRISPR-Cas9 screens for therapeutic discovery in facioscapulohumeral muscular dystrophy
The emergence of CRISPR-Cas9 gene-editing technologies and genome-wide CRISPR-
Cas9 libraries enables efficient unbiased genetic screening that can accelerate the process …
Cas9 libraries enables efficient unbiased genetic screening that can accelerate the process …
The p150 isoform of ADAR1 blocks sustained RLR signaling and apoptosis during influenza virus infection
Signaling through retinoic acid inducible gene I (RIG-I) like receptors (RLRs) is tightly
regulated, with activation occurring upon sensing of viral nucleic acids, and suppression …
regulated, with activation occurring upon sensing of viral nucleic acids, and suppression …
Influenza A virus infection activates STAT3 to enhance SREBP2 expression, cholesterol biosynthesis, and virus replication
J Zhang, Y Wu, Y Wang, P Liu, K Liu, J Sun, P Zhang… - Iscience, 2024 - cell.com
Cellular cholesterol plays an important role in influenza A virus (IAV) endocytosis and
replication. However, how IAV infection regulates cholesterol biosynthesis remains poorly …
replication. However, how IAV infection regulates cholesterol biosynthesis remains poorly …
Genome-wide CRISPR-Cas9 screen reveals the importance of the heparan sulfate pathway and the conserved oligomeric Golgi complex for synthetic double …
Double-stranded RNA (dsRNA) is the hallmark of many viral infections. dsRNA is produced
either by RNA viruses during replication or by DNA viruses upon convergent transcription …
either by RNA viruses during replication or by DNA viruses upon convergent transcription …
The RNA-Splicing Ligase RTCB Promotes Influenza A Virus Replication by Suppressing Innate Immunity via Interaction with RNA Helicase DDX1
L Cao, X Hui, T Xu, H Mao, X Lin, K Huang… - The Journal of …, 2023 - journals.aai.org
The RNA-splicing ligase RNA 29, 39-cyclic phosphate and 59-OH ligase (RTCB) is a
catalytic subunit of the tRNA-splicing ligase complex, which plays an essential role in …
catalytic subunit of the tRNA-splicing ligase complex, which plays an essential role in …
Computational methods in the analysis of viral-host interactions
OA Tarasova, SM Ivanov, NY Biziukova… - … , QSAR and Machine …, 2023 - Elsevier
Viruses play an important role in humanity since they can disrupt people's life significantly.
Dissemination of the most known viruses in a population can be prevented by vaccination …
Dissemination of the most known viruses in a population can be prevented by vaccination …
Synthetically engineered IgG1 antibody Fc fragments presenting influenza A virus receptor sialic acid inhibit viral haemagglutination activity, but enhance virus …
C Vrettou, P Blundell, ER Gaunt, RJ Pleass - bioRxiv, 2022 - biorxiv.org
Many clinically important viruses, including influenza A, SARS-CoV-1, adenoviruses, and
DNA tumour viruses such as Kaposi's sarcoma herpesvirus use multivalent binding to sialic …
DNA tumour viruses such as Kaposi's sarcoma herpesvirus use multivalent binding to sialic …
[BOOK][B] Bringing High-Throughput Data Analysis to Biologists
CS Magnano - 2022 - search.proquest.com
Large-scale biological datasets, such as transcriptomic, proteomic, and other high-
throughput assays, are routinely applied to characterize cellular states. While there is a …
throughput assays, are routinely applied to characterize cellular states. While there is a …