MRI has improved the diagnostic work-up of multiple sclerosis, but inappropriate image
interpretation and application of MRI diagnostic criteria contribute to misdiagnosis. Some …

Quantitative MRI provides biophysical measures of the microstructural integrity of the CNS,
which can be compared across CNS regions, patients, and centres. In patients with multiple …

Despite therapeutic suppression of relapses, multiple sclerosis (MS) patients often
experience subtle deterioration, which extends beyond the definition of “progression …

Destruction of oligodendrocytes and myelin sheaths in cortical gray matter profoundly alters
neural activity and is associated with cognitive disability in multiple sclerosis (MS). Myelin …

Objective To noninvasively assess myelin status in chronic white matter lesions of multiple
sclerosis (MS), we developed and evaluated a simple classification scheme based on T1 …

Brain imaging is increasingly used to support clinicians in diagnosing multiple sclerosis
(MS) and monitoring its progression. However, the role of magnetic resonance imaging …

Spinal cord lesions detected on MRI hold important diagnostic and prognostic value for
multiple sclerosis. Previous attempts to correlate lesion burden with clinical status have had …

In multiple sclerosis, individual lesion-type patterns on magnetic resonance imaging might
be valuable for predicting clinical outcome and monitoring treatment effects …

Background Cortical lesions develop early in multiple sclerosis (MS) and play a major role in
disease progression. MRI at 7.0 T shows high sensitivity for detection of cortical lesions as …

Focal lesions in both white and gray matter are characteristic of multiple sclerosis (MS).
Histopathological studies have helped define the main underlying pathological processes …