Receptor tyrosine kinase signalling pathways have been successfully targeted to inhibit
proliferation and angiogenesis for cancer therapy. However, kinase deregulation has been …

RNA-binding proteins (RBPs) regulate essentially every event in the lifetime of an RNA
molecule, from its production to its destruction. Whereas much has been learned about RNA …

Dysregulated RNA splicing is a molecular feature that characterizes almost all tumour types.
Cancer-associated splicing alterations arise from both recurrent mutations and altered …

Vascular endothelial growth factor-A (VEGF-A) is a key mediator of angiogenesis, signalling
via the class IV tyrosine kinase receptor family of VEGF Receptors (VEGFRs). Although …

Multiple coronaviruses have emerged independently in the past 20 years that cause lethal
human diseases. Although vaccine development targeting these viruses has been …

Discoveries in the past decade have highlighted the potential of mRNA as a therapeutic
target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations …

Alternative splicing of pre-mRNA allows the generation of multiple splice isoforms from a
given gene, which can have distinct functions. In fact, splice isoforms can have opposing …

Background Angiogenesis is the process by which new blood vessels arise from pre-
existing ones. Fibroblast growth factor-2 (FGF-2), a leading member of the FGF family of …

PRMT1 plays a vital role in breast tumorigenesis; however, the underlying molecular
mechanisms remain incompletely understood. Herein, we show that PRMT1 plays a critical …

The SRPK family of kinases regulates pre-mRNA splicing by phosphorylating
serine/arginine (SR)-rich splicing factors, signals splicing control in response to extracellular …