Mitochondria are dynamic organelles with multiple functions. They participate in necrotic cell
death and programmed apoptotic, and are crucial for cell metabolism and survival …

Selective autophagy is the lysosomal degradation of specific intracellular components
sequestered into autophagosomes, late endosomes, or lysosomes through the activity of …

Efficient proteostasis is crucial for somatic maintenance, and its decline during aging leads
to cellular dysfunction and disease. Selective autophagy is a form of autophagy mediated by …

To achieve homeostasis, cells evolved dynamic and self-regulating quality control
processes to adapt to new environmental conditions and to prevent prolonged damage. We …

Selective autophagy relies on soluble or membrane-bound cargo receptors that recognize
cargo and bring about autophagosome formation at the cargo. The cargo-bound receptors …

Post-translational modifications, such as phosphorylation, ubiquitination and acetylation,
play crucial roles in the regulation of autophagy. Acetylation has emerged as an important …

Autophagy is a conserved lysosomal degradation pathway where cellular components are
dynamically degraded and re-processed to maintain physical homeostasis. However, the …

In selective autophagy, cytoplasmic components are selected and tagged before being
sequestered into an autophagosome by means of selective autophagy receptors such as …

Autophagy is a highly conserved catabolic process cells use to maintain their homeostasis
by degrading misfolded, damaged and excessive proteins, nonfunctional organelles, foreign …

Lysosomes are the main proteolytic compartments of mammalian cells comprising of a
battery of hydrolases. Lysosomes dispose and recycle extracellular or intracellular …