Cancer has myriad effects on metabolism that include both rewiring of intracellular
metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor …

Vitamins B9 (folate) and B12 are essential water-soluble vitamins that play a crucial role in
the maintenance of one-carbon metabolism: a set of interconnected biochemical pathways …

Environmental nutrient availability influences T cell metabolism, impacting T cell function
and sha** immune outcomes. Here, we identified ketone bodies (KBs)—including β …

Understanding cellular metabolism holds immense potential for develo** new classes of
therapeutics that target metabolic pathways in cancer. Metabolic pathways are altered in …

Problem Tumor recurrence is a major clinical issue that represents the principal cause of
cancer-related deaths, with few targetable common pathways. Mechanisms by which …

Metabolic reprogramming is widely observed during cancer development to confer cancer
cells the ability to survive and proliferate, even under the stressed, such as nutrient-limiting …

Glucose and amino acids are key nutrients supporting cell growth. Amino acids are imported
as monomers, but an alternative route induced by oncogenic KRAS involves uptake of …

One-carbon metabolism involving the folate and methionine cycles integrates nutritional
status from amino acids, glucose and vitamins, and generates diverse outputs, such as the …

Rationale: Dysregulation of cellular metabolism has been shown to participate in several
pathologic processes. However, the role of metabolic reprogramming is not well appreciated …

Compared to normal cells, cancer cells strongly upregulate glucose uptake and glycolysis to
give rise to increased yield of intermediate glycolytic metabolites and the end product …