Ets1 belongs to the large family of the ETS domain family of transcription factors and is
involved in cancer progression. In most carcinomas, Ets1 expression is linked to poor …

Cerebrovascular dysregulation is a hallmark of Alzheimer's disease (AD), but the changes
that occur in specific cell types have not been fully characterized. Here, we profile single …

Background Sporadic arteriovenous malformations of the brain, which are morphologically
abnormal connections between arteries and veins in the brain vasculature, are a leading …

Enhancer elements are genomic regulatory sequences that direct the selective expression
of genes so that genetically identical cells can differentiate and acquire the highly …

Vascular endothelial growth factor (VEGF) is a major driver of blood vessel formation.
However, the signal transduction pathways culminating in the biological consequences of …

Background—Long noncoding RNAs (lncRNAs) have recently been implicated in many
biological processes and diseases. Atherosclerosis is a major risk factor for cardiovascular …

Transcription factors (TFs) play a crucial role in regulating the dynamic and precise patterns
of gene expression required for the initial specification of endothelial cells (ECs), and during …

It remains poorly understood about the regulation of gene and transposon transcription
during human early embryogenesis. Here, we report that broad H3K27ac domains are …

The rapid increase of genome-wide datasets on gene expression, chromatin states, and
transcription factor (TF) binding locations offers an exciting opportunity to interpret the …

Post-transcriptional modifications play pivotal roles in various pathological processes and
ischemic disorders. However, the role of N7-methylguanosine (m7G), particularly m7G in …