The observation and analysis of intra-tumour heterogeneity (ITH), particularly in genomic
studies, has advanced our understanding of the evolutionary forces that shape cancer …

Enhancers are genomic sequences that play a key role in regulating tissue-specific gene
expression levels. An increasing number of diseases are linked to impaired enhancer …

Cancer is driven by genetic change, and the advent of massively parallel sequencing has
enabled systematic documentation of this variation at the whole-genome scale,–. Here we …

Primary lymphomas of the central nervous system (PCNSL) are mainly diffuse large B-cell
lymphomas (DLBCLs) confined to the central nervous system (CNS). Molecular drivers of …

Although often located at a distance from their target gene promoters, enhancers are the
primary genomic determinants of temporal and spatial transcriptional specificity in …

To increase understanding of the genomic landscape of acral melanoma, a rare form of
melanoma occurring on palms, soles or nail beds, whole genome sequencing of 87 tumors …

Both proteome and transcriptome data can help assess the relevance of non-coding somatic
mutations in cancer. Here, we combine mass spectrometry-based proteomics data with …

Cancer genomes have been explored from the early 2000s through massive exome
sequencing efforts, leading to the publication of The Cancer Genome Atlas in 2013 …

Cancer is generally characterized by acquired genomic aberrations in a broad spectrum of
types and sizes, ranging from single nucleotide variants to structural variants (SVs). At least …

Melanomas can have multiple coexisting cell states, including proliferative (PRO) versus
invasive (INV) subpopulations that represent a" go or grow" trade-off; however, how these …