Bionanoparticles in cancer imaging, diagnosis, and treatment

Y Li, Q Bao, S Yang, M Yang, C Mao - View, 2022 - Wiley Online Library
Biological molecules such as DNA, proteins, and lipids can be assembled into naturally
existing nanoparticles, such as bacterial viruses (also called bacteriophages or phages) …

[HTML][HTML] Applications and developments of gene therapy drug delivery systems for genetic diseases

X Pan, H Veroniaina, N Su, K Sha, F Jiang… - Asian journal of …, 2021 - Elsevier
Genetic diseases seriously threaten human health and have always been one of the
refractory conditions facing humanity. Currently, gene therapy drugs such as siRNA, shRNA …

MicroRNA-129 and-335 promote diabetic wound healing by inhibiting Sp1-mediated MMP-9 expression

W Wang, C Yang, XY Wang, LY Zhou, GJ Lao, D Liu… - Diabetes, 2018 - Am Diabetes Assoc
Diabetic wounds are recalcitrant to healing. However, the mechanism causing this
dysfunction is not fully understood. High expression of matrix metalloproteinase-9 (MMP-9) …

TRAIL-based gene delivery and therapeutic strategies

H Zhong, H Wang, J Li, Y Huang - Acta Pharmacologica Sinica, 2019 - nature.com
TRAIL (tumor necrosis factor-related apoptosis-inducing ligand), also known as APO2L,
belongs to the tumor necrosis factor family. By binding to the death receptor 4 (DR4) or DR5 …

Towards clinical implementation of adeno-associated virus (AAV) vectors for cancer gene therapy: current status and future perspectives

UT Hacker, M Bentler, D Kaniowska, M Morgan… - Cancers, 2020 - mdpi.com
Adeno-associated virus (AAV) vectors have gained tremendous attention as in vivo delivery
systems in gene therapy for inherited monogenetic diseases. First market approvals …

Sinoporphyrin sodium based sonodynamic therapy induces anti-tumor effects in hepatocellular carcinoma and activates p53/caspase 3 axis

E Li, Y Sun, G Lv, Y Li, Z Zhang, Z Hu, W Cao - The International Journal of …, 2019 - Elsevier
Sonodynamic therapy (SDT) is a noninvasive therapeutic method via the activation of certain
chemical sensitizers using low intensity ultrasound. In this work, we evaluated the antitumor …

MicroRNA-based drugs for brain tumors

S Anthiya, A Griveau, C Loussouarn, P Baril, M Garnett… - Trends in cancer, 2018 - cell.com
MicroRNAs (miRNAs) are key regulatory elements encoded by the genome. A single miRNA
can downregulate the expression of multiple genes involved in diverse functions. Because …

MicroRNA-221: A fine tuner and potential biomarker of chronic liver injury

J Markovic, AD Sharma, A Balakrishnan - Cells, 2020 - mdpi.com
The last decade has witnessed significant advancements in our understanding of how small
noncoding RNAs, such as microRNAs (miRNAs), regulate disease progression. One such …

Nitric oxide/paclitaxel micelles enhance anti-liver cancer effects and paclitaxel sensitivity by inducing ferroptosis, endoplasmic reticulum stress and pyroptosis

H Li, X Deng, Z Zhang, Z Yang, H Huang, X Ye… - RSC …, 2023 - pubs.rsc.org
The objective of this study was to investigate the anticancer activities of biodegradable
polymeric micelles composed of monomethoxy poly (ethylene glycol), polylactic acid, and …

Recent advances in various adeno-associated viruses (AAVs) as gene therapy agents in hepatocellular carcinoma

M Hadi, O Qutaiba B. Allela, M Jabari, AM Jasoor… - Virology Journal, 2024 - Springer
Primary liver cancer, which is scientifically referred to as hepatocellular carcinoma (HCC), is
a significant concern in the field of global health. It has been demonstrated that conventional …