The extracellular matrix is a fundamental, core component of all tissues and organs, and is
essential for the existence of multicellular organisms. From the earliest stages of organism …

Primary tumors actively and specifically prime pre-metastatic niches (PMNs), the future sites
of organotropic metastasis, preparing these distant microenvironments for disseminated …

Tissues are dynamically shaped by bidirectional communication between resident cells and
the extracellular matrix (ECM) through cell-matrix interactions and ECM remodelling …

The tumour stroma, and in particular the extracellular matrix (ECM), is a salient feature of
solid tumours that plays a crucial role in sha** their progression. Many desmoplastic …

Integrin receptors are the main molecular link between cells and the extracellular matrix
(ECM) as well as mediating cell–cell interactions. Integrin–ECM binding triggers the …

The extracellular matrix (ECM) is a complex assembly of proteins that constitutes the scaffold
organizing cells, tissues, and organs. Over the past decade, mass-spectrometry-based …

Cancer cells disseminate and seed in distant organs, where they can remain dormant for
many years before forming clinically detectable metastases. Here we studied how …

The extracellular matrix (ECM) is a complex assembly of hundreds of proteins forming the
architectural scaffold of multicellular organisms. In addition to its structural role, the ECM …

Metastasis has long been understood to lead to the overwhelming majority of cancer-related
deaths. However, our understanding of the metastatic process, and thus our ability to …

Collagen is one of the most abundant proteins in animals and a major component of the
extracellular matrix (ECM) in tissues. Besides playing a role as a structural building block of …