[HTML][HTML] Enhancing translation: A need to leverage complex preclinical models of addictive drugs to accelerate substance use treatment options

C Corley, A Craig, S Sadek, JA Marusich… - Pharmacology …, 2024 - Elsevier
Preclinical models of addictive drugs have been developed for decades to model aspects of
the clinical experience in substance use disorders (SUDs). These include passive exposure …

Repeated exposure to physiologically effective doses of contraceptive hormones ethinyl estradiol or levonorgestrel do not alter the reinforcing effects of a brief visual …

KR McNealy, MW Oevermann, MKL Knabel… - Hormones and …, 2024 - Elsevier
Estradiol and progesterone potentiate and attenuate reward processes, respectively.
Despite these well-characterized effects, there is minimal research on the effects of synthetic …

[HTML][HTML] Impacts of xylazine on fentanyl demand, body weight, and acute withdrawal in rats: A comparison to lofexidine

SM Sadek, SN Khatri, Z Kipp, KE Dunn… - …, 2024 - Elsevier
The opioid use landscape has recently shifted to include xylazine, a veterinary anesthetic,
as an adulterant in the fentanyl supply. The health impacts of xylazine as an emerging …