The limitations associated with natural enzyme catalysis have triggered the rise of the field of
protein engineering. Traditional rational design was based on the analysis of protein …

Flavoprotein monooxygenases (FPMOs) are single-or two-component enzymes that
catalyze a diverse set of chemo-, regio-and enantioselective oxyfunctionalization reactions …

Pollution, accidents, and misinformation have earned the pharmaceutical and chemical
industry a poor public reputation, despite their undisputable importance to society …

Enzyme-based synthetic chemistry provides a green way to synthesize industrially important
chemical scaffolds and provides incomparable substrate specificity and unmatched stereo …

Detoxication, or 'drug‐metabolizing', enzymes and drug transporters exhibit remarkable
substrate promiscuity and catalytic promiscuity. In contrast to substrate‐specific enzymes …

Enzymes often by far exceed the activity, selectivity, and sustainability achieved with
chemical catalysts. One of the main reasons for the lack of biocatalysis in the chemical …

Highlights•Monooxygenases (MOs) face a challenging reaction, requiring the coordination
of three substrates by the same active site.•To address this challenge, these enzymes …

Promiscuous enzymes play a crucial role in organism survival and new reaction mining.
However, comprehensive map** of the catalytic and regulatory mechanisms hasn't been …

Baeyer-Villiger monooxygenase (BVMO) mediated sulfoxidation is a sustainable approach
for the synthesis of esomeprazole. In this work, a novel phenylacetone monooxygenase from …

Proteins are inherently dynamic, and proper enzyme function relies on conformational
flexibility. In this study, we demonstrated how an active site residue changes an enzyme's …