Current detection technologies for circulating tumor cells

Z Shen, A Wu, X Chen - Chemical Society Reviews, 2017 - pubs.rsc.org
Circulating tumor cells (CTCs) are cancer cells that circulate in the blood stream after being
naturally shed from original or metastatic tumors, and can lead to a new fatal metastasis …

Rare cell isolation and analysis in microfluidics

Y Chen, P Li, PH Huang, Y **e, JD Mai, L Wang… - Lab on a Chip, 2014 - pubs.rsc.org
Rare cells are low-abundance cells in a much larger population of background cells.
Conventional benchtop techniques have limited capabilities to isolate and analyze rare cells …

Isolation of circulating tumor cells by dielectrophoresis

PRC Gascoyne, S Shim - Cancers, 2014 - mdpi.com
Dielectrophoresis (DEP) is an electrokinetic method that allows intrinsic dielectric properties
of suspended cells to be exploited for discrimination and separation. It has emerged as a …

Multivalent capture and detection of cancer cells with DNA nanostructured biosensors and multibranched hybridization chain reaction amplification

G Zhou, M Lin, P Song, X Chen, J Chao… - Analytical …, 2014 - ACS Publications
Sensitive detection of cancer cells plays a critically important role in the early detection of
cancer and cancer metastasis. However, because circulating tumor cells are extremely rare …

Probing circulating tumor cells in microfluidics

P Li, ZS Stratton, M Dao, J Ritz, TJ Huang - Lab on a Chip, 2013 - pubs.rsc.org
Circulating tumor cells (CTCs) are important targets for study as we strive to better
understand, diagnose, and treat cancers. However, CTCs are found in blood at extremely …

Measuring single cell mass, volume, and density with dual suspended microchannel resonators

AK Bryan, VC Hecht, W Shen, K Payer, WH Grover… - Lab on a Chip, 2014 - pubs.rsc.org
Cell size, measured as either volume or mass, is a fundamental indicator of cell state. Far
more tightly regulated than size is density, the ratio between mass and volume, which can …

[HTML][HTML] Application of microfluidic technology based on surface-enhanced Raman scattering in cancer biomarker detection: A review

C Nie, I Shaw, C Chen - Journal of Pharmaceutical Analysis, 2023 - Elsevier
With the continuous discovery and research of predictive cancer-related biomarkers, liquid
biopsy shows great potential in cancer diagnosis. Surface-enhanced Raman scattering …

Enrichment, detection and clinical significance of circulating tumor cells

SK Arya, B Lim, ARA Rahman - Lab on a Chip, 2013 - pubs.rsc.org
Circulating Tumor Cells (CTCs) are shed from primary or secondary tumors into blood
circulation. Accessing and analyzing these cells provides a non-invasive alternative to tissue …

DNA/RNA preparation for molecular detection

SA Thatcher - Clinical chemistry, 2015 - academic.oup.com
BACKGROUND Effective upstream preparation of nucleic acid (NA) is important for
molecular techniques that detect unique DNA or RNA sequences. The isolated NA should …

Circulating tumor cells: technologies and their clinical potential in cancer metastasis

J **ao, PR Pohlmann, C Isaacs, BA Weinberg, AR He… - Biomedicines, 2021 - mdpi.com
Circulating tumor cells (CTCs) are single cells or clusters of cells within the circulatory
system of a cancer patient. While most CTCs will perish, a small proportion will proceed to …